Evidence map›Paper›PMID 32523103›Full record

ArticleNature communications2020

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3).

Alexander J Knights, Emily J Vohralik, Peter J Houweling, Elizabeth S Stout, Laura J Norton, Stephanie J Alexopoulos, Jinfen J Yik, Hanapi Mat Jusoh, Ellen M Olzomer, Kim S Bell-Anderson and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Tissue adaptation of eosinophils.Journal of leukocyte biology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. KLF feedback loops in innate immunity.Frontiers in immunology · 2025
    Review
  10. Eosinophils prevent diet-induced airway hyperresponsiveness in mice on a high-fat diet.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Alexander J KnightsSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0001-8402-2212
Emily J VohralikSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Peter J HouwelingMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, 3052, Australia.
Elizabeth S StoutSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Laura J NortonSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Stephanie J AlexopoulosSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Jinfen J YikSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Hanapi Mat JusohCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.
Ellen M OlzomerSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.
Kim S Bell-AndersonCharles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia.
Kathryn N NorthMurdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, 3052, Australia.
Kyle L HoehnSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0002-0214-3238
Merlin CrossleySchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia.ORCID http://orcid.org/0000-0003-2057-3642
Kate G R QuinlanSchool of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia. kate.quinlan@unsw.edu.au.ORCID http://orcid.org/0000-0002-5722-8183
UNSW Sydney · AURoyal Children's Hospital · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The conversion of white adipocytes to thermogenic beige adipocytes represents a potential mechanism to treat obesity and related metabolic disorders. However, the mechanisms involved in converting white to beige adipose tissue remain incompletely understood. Here we show profound beiging in a genetic mouse model lacking the transcriptional repressor Krüppel-like factor 3 (KLF3). Bone marrow transplants from these animals confer the beige phenotype on wild type recipients. Analysis of the cellular and molecular changes reveal an accumulation of eosinophils in adipose tissue. We examine the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging. Furthermore, we provide evidence that eosinophils may directly act on adipocytes to drive beiging and highlight the critical role of these little-understood immune cells in thermogenesis.

Indexed as

Adipose TissueAdiposityAnimalsChlorocebus aethiopsChromatin ImmunoprecipitationCOS CellsEosinophilsFlow CytometryKruppel-Like Transcription FactorsMaleMiceObesitySignal TransductionSoftwareKlf3 protein, mouseKruppel-Like Transcription Factors

Identifiers

PMID32523103
PMCPMC7286919
OpenAlexW3032900131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.