ArticleScientific reports2020
Discovery of os cordis in the cardiac skeleton of chimpanzees (Pan troglodytes).
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Anatomy, Histology, Aetiology, Development and Functions of Cartilago Cordis: A Systematic Review.Cells, tissues, organs · 2025Pooled it
- Anatomy, histology, development and functions of Ossa cordis: A review.Anatomia, histologia, embryologia · 2022Pooled it
- Discovery of novel biomarkers associated with myocardial fibrosis in chimpanzees (Frontiers in veterinary science · 2026Article
- 3D anatomy of the heart in teaching: differentiating physiological and pathological changes in wild ungulates in central Europe.Frontiers in veterinary science · 2026Article
- Pericardial Metaplastic Ossification With Widespread Bone Formation: A Case Report.Case reports in pathology · 2026Article
- 3D visualization and printing: An "Anatomical Engineering" trend revealing underlying morphology via innovation and reconstruction towards future of veterinary anatomy.Anatomical science international · 2024Review
- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
- Ossa cordis and os aorta in the one-humped camel: Computed tomography, light microscopy and morphometric analysis.Microscopy research and technique · 2023Article
- Vitamin D status in chimpanzees in human care: a Europe wide study.Scientific reports · 2022Review
- Anatomical features of ossa cordis in the Steller sea lion.The Journal of veterinary medical science · 2022Article
- Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves.Journal of cardiovascular development and disease · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases, especially idiopathic myocardial fibrosis, is one of the most significant causes of morbidity and mortality in captive great apes. This study compared the structure and morphology of 16 hearts from chimpanzees (Pan troglodytes) which were either healthy or affected by myocardial fibrosis using X-ray microtomography. In four hearts, a single, hyperdense structure was detected within the right fibrous trigone of the cardiac skeleton. High resolution scans and histopathology revealed trabecular bones in two cases, hyaline cartilage in another case and a focus of mineralised fibro-cartilaginous metaplasia with endochondral ossification in the last case. Four other animals presented with multiple foci of ectopic calcification within the walls of the great vessels. All hearts affected by marked myocardial fibrosis presented with bone or cartilage formation, and increased collagen levels in tissues adjacent to the bone/cartilage, while unaffected hearts did not present with os cordis or cartilago cordis. The presence of an os cordis has been described in some ruminants, camelids, and otters, but never in great apes. This novel research indicates that an os cordis and cartilago cordis is present in some chimpanzees, particularly those affected by myocardial fibrosis, and could influence the risk of cardiac arrhythmias and sudden death.
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