ArticleNature communications2020
Overcoming evanescent field decay using 3D-tapered nanocavities for on-chip targeted molecular analysis.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- All-optical control of high-purity trions in nanoscale waveguide.Nature communications · 2023Article
- Coupled surface plasmon-phonon polariton nanocavity arrays for enhanced mid-infrared absorption.Nanophotonics (Berlin, Germany) · 2022Article
- Accessing Plasmonic Hotspots Using Nanoparticle-on-Foil Constructs.ACS photonics · 2021Article
- Novel Photonic Bio-Chip Sensor Based on Strained Graphene Sheets for Blood Cell Sorting.Molecules (Basel, Switzerland) · 2021Article
- High Performance of a Metal Layer-Assisted Guided-Mode Resonance Biosensor Modulated by Double-Grating.Biosensors · 2021Article
- Resonant Subwavelength and Nano-Scale Grating Structures for Biosensing Application: A Comparative Study.Sensors (Basel, Switzerland) · 2021Article
- Review
- Biosensors-on-Chip: An Up-to-Date Review.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enhancement of optical emission on plasmonic nanostructures is intrinsically limited by the distance between the emitter and nanostructure surface, owing to a tightly-confined and exponentially-decaying electromagnetic field. This fundamental limitation prevents efficient application of plasmonic fluorescence enhancement for diversely-sized molecular assemblies. We demonstrate a three-dimensionally-tapered gap plasmon nanocavity that overcomes this fundamental limitation through near-homogeneous yet powerful volumetric confinement of electromagnetic field inside an open-access nanotip. The 3D-tapered device provides fluorescence enhancement factors close to 2200 uniformly for various molecular assemblies ranging from few angstroms to 20 nanometers in size. Furthermore, our nanostructure allows detection of low concentration (10 pM) biomarkers as well as specific capture of single antibody molecules at the nanocavity tip for high resolution molecular binding analysis. Overcoming molecule position-derived large variations in plasmonic enhancement can propel widespread application of this technique for sensitive detection and analysis of complex molecular assemblies at or near single molecule resolution.
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Registered trials
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