ArticleNature communications2020
A synthetic ion channel with anisotropic ligand response.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Artificial Transmembrane Channels for Selective Ascorbic Acid Transport and Bioorthogonal Signal Transduction.Angewandte Chemie (International ed. in English) · 2026Article
- Multistep receptor binding of the hepatitis B virus preS1 domain.Nature communications · 2026Article
- Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter.PLoS pathogens · 2026Article
- Molecular prosthetics for CFTR designed for anion selectivity outperform amphotericin B in cultured cystic fibrosis airway epithelia.bioRxiv : the preprint server for biology · 2025Article
- Aromatic Anion Carrier via Self-Assembly with Imidazolium-Fused Aromatic Amphiphiles.Precision chemistry · 2025Article
- Real-time visualization reveals Mycobacterium tuberculosis ESAT-6 disrupts phagosome-like compartment via fibril-mediated vesiculation.Cell reports · 2025Article
- Structural basis for hepatitis B virus restriction by a viral receptor homologue.Nature communications · 2024Article
- Constructing artificial gap junctions to mediate intercellular signal and mass transport.Nature chemistry · 2024Article
- Lipid vesicle-based molecular robots.Lab on a chip · 2024Review
- Structural basis for ligand recognition and signaling of hydroxy-carboxylic acid receptor 2.Nature communications · 2023Article
- CHARMM-GUIJournal of chemical theory and computation · 2023Review
- Cell-Free Synthesis and Electrophysiological Analysis of Multipass Voltage-Gated Ion Channels Tethered in Microsomal Membranes.Advances in biochemical engineering/biotechnology · 2023Article
- Cholesterol-stabilized membrane-active nanopores with anticancer activities.Nature communications · 2022Article
- Structure of SARS-CoV-2 membrane protein essential for virus assembly.Nature communications · 2022Article
- A reversibly gated protein-transporting membrane channel made of DNA.Nature communications · 2022Article
- Supramolecular chemistry in lipid bilayer membranes.Chemical science · 2021Review
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biological membranes play pivotal roles in the cellular activities. Transmembrane proteins are the central molecules that conduct membrane-mediated biochemical functions such as signal transduction and substance transportation. Not only the molecular functions but also the supramolecular properties of the transmembrane proteins such as self-assembly, delocalization, orientation and signal response are essential for controlling cellular activities. Here we report anisotropic ligand responses of a synthetic multipass transmembrane ion channel. An unsymmetrical molecular structure allows for oriented insertion of the synthetic amphiphile to a bilayer by addition to a pre-formed membrane. Complexation with a ligand prompts ion transportation by forming a supramolecular channel, and removal of the ligand deactivates the transportation function. Biomimetic regulation of the synthetic channel by agonistic and antagonistic ligands is also demonstrated not only in an artificial membrane but also in a biological membrane of a living cell.
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