Evidence map›Paper›PMID 32522889›Full record

ArticleRNA (New York, N.Y.)2020

Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly.

Hossein Shenasa, Maliheh Movassat, Elmira Forouzmand, Klemens J Hertel

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Alternative splicing and cancer: a systematic review.Signal transduction and targeted therapy · 2021
    Pooled it
  2. Article
  3. Long-Read Sequencing Reveals RNA Splicing Complexity in Human Diseases.Computational and structural biotechnology journal · 2026
    Review
  4. Alternative splicing in ovarian cancer.Cell communication and signaling : CCS · 2024
    Review
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  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hossein ShenasaDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, California 92697, USA.
Maliheh MovassatDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, California 92697, USA.
Elmira ForouzmandDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, California 92697, USA.
Klemens J HertelDepartment of Microbiology and Molecular Genetics, University of California Irvine, Irvine, California 92697, USA.
University of California, Irvine · US

Funding

MECHANISMS OF ENHANCER DEPENDENT SPLICE SITE ACTIVATIONR01GM062287 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HERTEL, KLEMENS J · 2001 to 2019
$4.8M
Tracking Gene Expression Dynamics from Transcription to DegradationR01GM110244 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI HERTEL, KLEMENS J · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM062287NIGMS NIH HHS R01 GM110244
6 · The paper itself

Abstract

Alternative splicing is responsible for much of the transcriptomic and proteomic diversity observed in eukaryotes and involves combinatorial regulation by many

Indexed as

Allosteric RegulationAlternative SplicingHeterogeneous-Nuclear RibonucleoproteinsProteomicsRibonucleoprotein, U1 Small NuclearRNA, MessengerRNA PrecursorsRNA, Small NuclearRNA Splice SitesSpliceosomesHeterogeneous-Nuclear RibonucleoproteinsRibonucleoprotein, U1 Small NuclearRNA, MessengerRNA PrecursorsRNA, Small NuclearRNA Splice SitesU1 small nuclear RNAallosteric regulationspliceosomal assemblysplice site selectionsplicing regulatory proteinsU1 snRNP

Identifiers

PMID32522889
PMCPMC7491332
OpenAlexW3033197841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.