ArticleProceedings of the National Academy of Sciences of the United States of America2020
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
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Who cites it
39 citing papers in PubMed, 66 citations in OpenAlex.
- Crystal Structure of Trabectedin-DNA Complex.Journal of molecular biology · 2026Article
- DNA polymerase I: structure, activity, and function in bacterial DNA replication and repair.Critical reviews in biochemistry and molecular biology · 2026Review
- Article
- The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.Nucleic acids research · 2026Article
- Role of tRNA-Derived Fragments and Their Modifications in the Pathogenesis and Treatment of Alzheimer's Disease.Molecular neurobiology · 2025Review
- Transcription-coupled repair: tangled up in convoluted repair.The FEBS journal · 2025Review
- RNA sculpting by the primordial Helix-clasp-Helix-Strand-Loop (HcH-SL) motif enforces chemical recognition enabling diverse KH domain functions.The Journal of biological chemistry · 2025Review
- Molecular model of TFIIH recruitment to the transcription-coupled repair machinery.Nature communications · 2025Article
- Review
- Article
- Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair.Nature communications · 2024Article
- Article
- Interplay of the Tfb1 pleckstrin homology domain with Rad2 and Rad4 in transcription coupled and global genomic nucleotide excision repair.Nucleic acids research · 2024Article
- Analysis of cytosine deamination events in excision repair sequencing reads reveals mechanisms of incision site selection in NER.Nucleic acids research · 2024Article
- A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions.Frontiers in molecular biosciences · 2024Article
- Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases.Nature communications · 2023Article
- A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair.Nucleic acids research · 2023Article
- The XPA Protein-Life under Precise Control.Cells · 2022Review
- Two interaction surfaces between XPA and RPA organize the preincision complex in nucleotide excision repair.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- XPG in the Nucleotide Excision Repair and Beyond: a study on the different functional aspects of XPG and its associated diseases.Molecular biology reports · 2022Review
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 1 country.
Susan E TsutakawaMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; setsutakawa@lbl.gov jdg@med.unc.edu PKCooper@lbl.gov jatainer@gmail.com.ORCID 0000-0002-4918-4571
Altaf H SarkerBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0001-6868-8460
Clifford NgBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-8581-7938
Andrew S ArvaiIntegrative Structural & Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.
David S ShinMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Brian ShihBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Shuai JiangBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Aye C ThwinBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Miaw-Sheue TsaiBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Alexandra WillcoxLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599.
Mai Zong HerMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Kelly S TregoBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Alan G RaetzBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
Daniel RosenbergMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0001-8017-8156
Albino BacollaDepartment of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030.ORCID 0000-0003-0206-8423
Michal HammelMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0002-5610-9289
Jack D GriffithLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 setsutakawa@lbl.gov jdg@med.unc.edu PKCooper@lbl.gov jatainer@gmail.com.
Priscilla K CooperBiological Systems and Engineering, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; setsutakawa@lbl.gov jdg@med.unc.edu PKCooper@lbl.gov jatainer@gmail.com.ORCID 0000-0002-3563-3647
John A TainerMolecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; setsutakawa@lbl.gov jdg@med.unc.edu PKCooper@lbl.gov jatainer@gmail.com.ORCID 0000-0003-1659-2429
Lawrence Berkeley National Laboratory · USThe University of Texas MD Anderson Cancer Center · USUniversity of North Carolina at Chapel Hill · USScripps Research Institute · US
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MTranscription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6MTHE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1MUser Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6MTraining in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8MMesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)R35CA220430 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI John A. Tainer · 2018 to 2026
$7.6MHOMOLOOUS RECOMBINATION: ITS MOLECULAR CYTOLOGYR01GM031819 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRIFFITH, JACK D · 1985 to 2017
$5.2MNucleoprotein structures formed at sites of DNA damageR01ES013773 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRIFFITH, JACK D · 2005 to 2015
$3.2MNovel Interactions of DNA Repair Processes in Replication Fork MaintenanceR01ES019935 · NIEHS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI COOPER, PRISCILLA K. · 2012 to 2016
$2.0MR-loops at the telomere as a toxic source of genomic instabilityR01ES031635 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRIFFITH, JACK D · 2020 to 2024
$1.7MIntegrative modeling of PCNA assemblies engaged in genome duplication and repairR01GM110387 · NIGMS · GEORGIA STATE UNIVERSITY · PI IVANOV, IVAYLO NIKOLAEV · 2015 to 2019
$1.7MNCI NIH HHS P01 CA092584NCI NIH HHS R35 CA220430NIA NIH HHS P01 AG017242NIA NIH HHS T32 AG000266NIEHS NIH HHS R01 ES013773NIEHS NIH HHS R01 ES019935NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM031819NIGMS NIH HHS R01 GM110387
Abstract
Xeroderma pigmentosum group G (XPG) protein is both a functional partner in multiple DNA damage responses (DDR) and a pathway coordinator and structure-specific endonuclease in nucleotide excision repair (NER). Different mutations in the XPG gene
Indexed as
Point MutationBinding SitesCockayne SyndromeConserved SequenceDNADNA-Binding ProteinsDNA Excision Repair Protein ERCC-5EndonucleasesEnzyme StabilityHumansMolecular Dynamics SimulationNuclear ProteinsPhenotypeProtein BindingProtein FoldingProtein MultimerizationDNADNA-Binding ProteinsDNA Excision Repair Protein ERCC-5EndonucleasesNuclear ProteinsTranscription Factorscrystallographycrystal structureelectron microscopyendonucleaseERCC5
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