ArticleJournal of virology2020
Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands.
Erratum issuedOpen access · greenAbstract read
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Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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31citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
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Who cites it
31 citing papers in PubMed, 41 citations in OpenAlex.
- HIV-1 Env Heterogeneity: Cleavage, Trafficking, and Antigenic Consequences for Virions and Infected Cells.Viruses · 2026Review
- Endocytic motif on HIV-1 Env regulates cleavage status and antibody neutralization of cell-free and cell-to-cell infection.Journal of virology · 2026Article
- Bioorthogonal click-chemistry labeling and visualization of dual noncanonical amino acid-incorporated HIV-1 Env on intact virions.Methods in enzymology · 2026Article
- Characterization of full-length and cytoplasmic tail-truncated envelope glycoproteins incorporated into human immunodeficiency virus (HIV-1) virions and virus-like particles.Journal of virology · 2025Article
- The membrane-proximal external region of human immunodeficiency virus (HIV-1) envelope glycoprotein trimers in A18-lipid nanodiscs.Communications biology · 2025Article
- Inducible cell lines producing replication-defective human immunodeficiency virus particles containing envelope glycoproteins stabilized in a pretriggered conformation.Journal of virology · 2024Article
- Conformations of membrane human immunodeficiency virus (HIV-1) envelope glycoproteins solubilized in Amphipol A18 lipid-nanodiscs.Journal of virology · 2024Article
- Membrane HIV-1 envelope glycoproteins stabilized more strongly in a pretriggered conformation than natural virus Envs.iScience · 2024Article
- Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function.Annual review of biophysics · 2024Review
- Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells.Journal of virology · 2024Article
- V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins.Journal of virology · 2023Article
- Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein pretriggered conformation.Journal of virology · 2023Article
- Impact of stabilizing mutations on the antigenic profile and glycosylation of membrane-expressed HIV-1 envelope glycoprotein.PLoS pathogens · 2023Article
- Conformations of Human Immunodeficiency Virus Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles.Journal of virology · 2023Article
- Asymmetric conformations of cleaved HIV-1 envelope glycoprotein trimers in styrene-maleic acid lipid nanoparticles.Communications biology · 2023Article
- Temsavir Modulates HIV-1 Envelope Conformation by Decreasing Its Proteolytic Cleavage.Viruses · 2023Article
- Characterization of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Conformational States on Infectious Virus Particles.Journal of virology · 2023Article
- Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound.Journal of virology · 2022Article
- Enhancement of CD4 Binding, Host Cell Entry, and Sensitivity to CD4bs Antibody Inhibition Conferred by a Natural but Rare Polymorphism in the HIV-1 Envelope.Journal of virology · 2022Article
- Regulation of epitope exposure in the gp41 membrane-proximal external region through interactions at the apex of HIV-1 Env.PLoS pathogens · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 5 institutions in 1 country.
Maolin LuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA maolin.lu@yale.edu walther.mothes@yale.edu.
Xiaochu MaDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Nick ReichardDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.
Daniel S TerryDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
James ArthosLaboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Amos B SmithDepartment of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Joseph G SodroskiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Scott C BlanchardDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Walther MothesDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA maolin.lu@yale.edu walther.mothes@yale.edu.ORCID 0000-0002-3367-7240
Yale University · USSt. Jude Children's Research Hospital · USHarvard University · USNational Institutes of Health · USUniversity of Pennsylvania · US
Funding
Understanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01AI150471 · NIAID · DREXEL UNIVERSITY · PI CHAIKEN, IRWIN M, MOTHES, WALTHER H · 2019 to 2022
$7.8MConformational Landscape of the HIV-1 Envelope GlycoproteinsR01AI124982 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2016 to 2025
$6.7MHIV-1 Env structure and function assessed by parallel smFRET and cryoETR01AI150560 · NIAID · YALE UNIVERSITY · PI BLANCHARD, SCOTT C, LIU, JUN · 2019 to 2022
$3.4MHIV-1 Env protein structure and function assessed by parallel smFRET and cryoETR37AI150560 · NIAID · YALE UNIVERSITY · PI WALTHER H MOTHES · 2023 to 2026
$3.2MNext-generation Fluorescent Probes for Biological ResearchR01GM098859 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI BLANCHARD, SCOTT C · 2012 to 2019
$2.9MEnrichment of the State-1 Conformation of the HIV-1 Envelope GlycoproteinR01AI145547 · NIAID · DANA-FARBER CANCER INST · PI SODROSKI, JOSEPH G · 2019 to 2021
$2.2MSingle molecule imaging of HIV-1 entryR01GM116654 · NIGMS · YALE UNIVERSITY · PI MOTHES, WALTHER H · 2015 to 2018
$1.6MNIAID NIH HHS P01 AI150471NIAID NIH HHS R01 AI124982NIAID NIH HHS R01 AI145547NIAID NIH HHS R01 AI150560NIAID NIH HHS R37 AI150560NIGMS NIH HHS R01 GM098859NIGMS NIH HHS R01 GM116654
Abstract
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer of gp120-gp41 heterodimers mediates virus entry into CD4-positive (CD4
Indexed as
Antibodies, NeutralizingCD4 AntigensCD4-Positive T-LymphocytesDisulfidesenv Gene Products, Human Immunodeficiency VirusGlycoproteinsHEK293 CellsHIV-1HIV AntibodiesHIV Envelope Protein gp120HIV Envelope Protein gp41HumansLigandsModels, MolecularProtein BindingProtein ConformationAntibodies, NeutralizingCD4 AntigensDisulfidesenv Gene Products, Human Immunodeficiency VirusGlycoproteinsHIV AntibodiesHIV Envelope Protein gp120HIV Envelope Protein gp41Ligandshuman immunodeficiency virussmFRETviral envelope proteinvirology
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.