Evidence map›Paper›PMID 32522811›Full record

Trial reportBMJ (Clinical research ed.)2020

Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial.

Noah M Ivers, Jon-David Schwalm, Zachary Bouck, Tara McCready, Monica Taljaard, Sherry L Grace, Jennifer Cunningham, Beth Bosiak, Justin Presseau, Holly O Witteman and 6 more

2 registry-linked trialsOpen access · hybridAbstract readMulticenter StudyPragmatic Clinical TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02382731 nacompletednot on this map

Interventions to Support Long-Term Adherence aNd Decrease Cardiovascular Events Post-Myocardial Infarction

TypeinterventionalSponsorWomen's College HospitalRan2015 to 2017Enrolled2,742ConditionsMyocardial Infarction, Coronary DiseaseArmsUsual care + letters, Usual care + letters + automated calls
NCT06882044 nacompletednot on this mapstarted 2021, after this paper: background citation

The Effect of a Mobile Application on Treatment Adherence, Self-Management, and Quality of Life in Patients With Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

TypeinterventionalSponsorTrakya UniversityRan2021 to 2024Enrolled61ConditionsAcute Myocardial Infarction (AMI), Mobile Health Technology (mHealth), Quality of Lifte, Treatment AdherenceArmsmHealth
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  4. Exercise-based cardiac rehabilitation for coronary heart disease.The Cochrane database of systematic reviews · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 1 country.

Noah M IversDepartment of Family and Community Medicine, Women's College Hospital, 76 Grenville Street, Toronto, ON, M5S1B2, Canada noah.ivers@utoronto.ca.ORCID 0000-0003-2500-2435
Jon-David SchwalmPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-2516-4952
Zachary BouckInstitute for Health Systems Solutions and Virtual Care, Women's College Hospital, Toronto, ON, Canada.ORCID 0000-0003-3145-1915
Tara McCreadyPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-4906-0747
Monica TaljaardOttawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-3978-8961
Sherry L GraceFaculty of Health, York University, Toronto, ON, Canada.ORCID 0000-0001-7063-3610
Jennifer CunninghamPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-8137-6779
Beth BosiakInstitute for Health Systems Solutions and Virtual Care, Women's College Hospital, Toronto, ON, Canada.ORCID 0000-0002-6856-879X
Justin PresseauOttawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0002-2132-0703
Holly O WittemanDepartment of Family and Emergency Medicine, Université Laval, Quebec City, QC, Canada.ORCID 0000-0003-4192-0682
Neville SuskinCardiac Rehabilitation and Secondary Prevention Programme of St Joseph's Health Care London, ON, Canada.ORCID 0000-0002-5456-1351
Harindra C WijeysunderaInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-8464-1080
Clare AtzemaInstitute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-7236-5522
R Sacha BhatiaInstitute for Health Systems Solutions and Virtual Care, Women's College Hospital, Toronto, ON, Canada.ORCID 0000-0001-6206-5318
Madhu NatarajanPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-6372-1348
Jeremy M GrimshawOttawa Hospital Research Institute, Ottawa, ON, Canada.ORCID 0000-0001-8015-8243
Population Health Research Institute · CAUniversity of Ottawa · CASunnybrook Health Science Centre · CAUniversity of Toronto · CAWomen's College Hospital · CAUniversité Laval · CAUniversity Health Network · CAWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo test a scalable health system intervention to improve long term adherence to secondary prevention treatments among patients who have had a recent myocardial infarction.

designThree arm, pragmatic randomised controlled trial with blinded outcome assessment.

settingNine cardiac centres in Ontario, Canada.

participants2632 patients with obstructive coronary artery disease after a myocardial infarction, identified from a centralised cardiac registry.

interventionsParticipants were randomised 1:1:1 to receive usual care, five mail-outs developed through a user centred design process, or mail-outs plus phone calls. The phone calls were delivered first by an interactive automated system to screen for non-adherence to treatment. Trained lay health workers followed up as necessary. Interventions were coordinated centrally but delivered from each patient's hospital site.

main outcome measuresCo-primary outcomes were completion of cardiac rehabilitation and adherence to recommended medication. Data were collected by blinded assessors through patient report and from administrative health databases at 12 months.

results2632 patients (mean age 66, 71% male) were randomised: 878 to the full intervention (mail plus phone calls), 878 to mail only, and 876 to usual care. Of the respondents, 174 (27%) of 643 in the usual care group, 200 (32%) of 628 in the mail only group, and 196 (37%) of 531 allocated to the full intervention completed cardiac rehabilitation (adjusted odds ratio 1.55, 95% confidence interval 1.18 to 2.03). In the mail plus phone group, 11.7%, 6.0%, 14.4%, 32.9%, and 35.0% reported adherence to 0, 1, 2, 3, and 4 drug classes after one year, respectively, in comparison with 12.5%, 6.8%, 13.6%, 30.2%, and 36.8% in the mail only group, and 12.2%, 8.4%, 13.1%, 30.3%, and 36.1% in the usual care group, respectively (mail only

conclusionsScalable interventions delivered by mail plus phone can increase completion of cardiac rehabilitation after myocardial infarction but not adherence to medication. More intensive interventions should be tested to improve adherence to medication and to evaluate the association between attendance at cardiac rehabilitation and adherence to medication.

trial registrationClinicalTrials.gov NCT02382731, registered 9 March 2015 before any patient enrolment.

Indexed as

Drug MonitoringAdrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsCardiac RehabilitationCoronary Artery DiseaseFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionOntarioPatient DropoutsPatient Education as TopicPlatelet Aggregation InhibitorsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation Inhibitors

Identifiers

PMID32522811
PMCPMC7284284
OpenAlexW3033513507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.