Evidence map›Paper›PMID 32522780›Full record

ArticlemSphere2020

Controlling the Growth of the Skin Commensal Staphylococcus epidermidis Using d-Alanine Auxotrophy.

David Dodds, Jeffrey L Bose, Ming-De Deng, Gilles R Dubé, Trudy H Grossman, Alaina Kaiser, Kashmira Kulkarni, Roger Leger, Sara Mootien-Boyd, Azim Munivar and 6 more

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Beneficial perspective onFrontiers in immunology · 2025
    Review
  8. Review
  9. Transient infection ofApplied and environmental microbiology · 2024
    Article
  10. Feasibility of engineeredBioengineering & translational medicine · 2024
    Article
  11. Review
  12. International journal of molecular sciences · 2023
    Article
  13. Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

David DoddsAzitra Inc., Farmington, Connecticut, USA.
Jeffrey L BoseDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0003-3394-9557
Ming-De DengBio-Technical Resources, Manitowoc, Wisconsin, USA.
Gilles R DubéAzitra Inc., Farmington, Connecticut, USA.
Trudy H GrossmanAzitra Inc., Farmington, Connecticut, USA.
Alaina KaiserAzitra Inc., Farmington, Connecticut, USA.
Kashmira KulkarniAzitra Inc., Farmington, Connecticut, USA.
Roger LegerAzitra Inc., Farmington, Connecticut, USA.
Sara Mootien-BoydAzitra Inc., Farmington, Connecticut, USA.
Azim MunivarAzitra Inc., Farmington, Connecticut, USA.
Julia OhJackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA.ORCID 0000-0002-5534-7023
Matthew PestrakAzitra Inc., Farmington, Connecticut, USA.
Komal RajpuraAzitra Inc., Farmington, Connecticut, USA.
Alexander P TikhonovAzitra Inc., Farmington, Connecticut, USA.
Traci TurecekAzitra Inc., Farmington, Connecticut, USA.
Travis WhitfillAzitra Inc., Farmington, Connecticut, USA travis.whitfill@yale.edu.ORCID 0000-0002-3277-4380
Bio-Technical Resources (United States) · USJackson Laboratory · USUniversity of Kansas Medical Center · USYale New Haven Hospital · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Using live microbes as therapeutic candidates is a strategy that has gained traction across multiple therapeutic areas. In the skin, commensal microorganisms play a crucial role in maintaining skin barrier function, homeostasis, and cutaneous immunity. Alterations of the homeostatic skin microbiome are associated with a number of skin diseases. Here, we present the design of an engineered commensal organism,

Indexed as

AlanineAnti-Bacterial AgentsBiofilmsBiological TherapyHumansMicrobiotaSkinStaphylococcus epidermidisSymbiosisAlanineAnti-Bacterial Agentsdermatologyengineeringgeneticslive biotherapeutic productsmicrobiomeskinsynthetic biologytherapeutics

Identifiers

PMID32522780
PMCPMC7289707
OpenAlexW3034006506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.