ArticleNeuroImage2020
The role of default mode network in semantic cue integration.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Tasks activating the default mode network map multiple functional systems.Brain structure & function · 2022Pooled it
- Separate neural networks of implicit emotional processing between pictures and words: A coordinate-based meta-analysis of brain imaging studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- Impact of Yoga Versus Memory Enhancement Training on Hippocampal Connectivity in Older Women at Risk for Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Trial
- Resolving the Abstract-Concrete Paradox in the Angular Gyrus: A Multimethod Investigation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A rostral prefrontal mediolateral gradient predicts creativity in frontotemporal dementia.Brain : a journal of neurology · 2026Article
- Model-based semantic distance reveals adaptive coordination of distinct cognitive systems in flexible knowledge retrieval.Nature communications · 2026Article
- Application of Electric-Field-Optimized Augmented Reality-Guided Neuronavigation in Transcranial Magnetic Stimulation.Journal of clinical medicine · 2026Article
- The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow.Nature neuroscience · 2025Article
- Diverse Frontoparietal Connectivity Supports Semantic Prediction and Integration in Sentence Comprehension.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A double dissociation between semantic and spatial cognition in visual to default network pathways.eLife · 2025Article
- Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models.NPP - digital psychiatry and neuroscience · 2025Article
- The changes in brain network functional gradients and dynamic functional connectivity in SeLECTS patients revealing disruptive and compensatory mechanisms in brain networks.Frontiers in psychiatry · 2025Article
- Article
- Article
- Eliminating episodic memory?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Alteration of multilayer network perspective on gray and white matter connectivity in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Brain functional gradient and structure features in adolescent and adult autism spectrum disorders.Human brain mapping · 2024Article
- Distinctive and Complementary Roles of Default Mode Network Subsystems in Semantic Cognition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Default mode network shows distinct emotional and contextual responses yet common effects of retrieval demands across tasks.Human brain mapping · 2024Article
- Functional gradients reveal cortical hierarchy changes in multiple sclerosis.Human brain mapping · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent accounts of large-scale cortical organisation suggest that the default mode network (DMN) is positioned at the top of a principal gradient, reflecting the separation between heteromodal and unimodal sensory-motor regions in patterns of connectivity and in geodesic distance along the cortical surface (Margulies et al., 2016). This isolation of DMN from external inputs might allow the integration of disparate sources of information that can constrain subsequent cognition. We tested this hypothesis by manipulating the degree to which semantic decisions for ambiguous words (e.g. jam) were constrained by preceding visual cues depicting relevant spatial contexts (e.g. supermarket or road) and/or facial emotions (e.g. happy vs. frustrated). We contrasted (i) the effects of a single preceding cue with a no-cue condition employing scrambled images, and (ii) convergent spatial and emotion cues with single cues. Single cues elicited stronger activation in the multiple demand network relative to no cues, consistent with the requirement to maintain information in working memory. The availability of two convergent cues elicited stronger activation within DMN regions (bilateral angular gyrus, middle temporal gyrus, medial prefrontal cortex, and posterior cingulate), even though behavioural performance was unchanged by cueing - consequently task difficulty is unlikely to account for the observed differences in brain activation. A regions-of-interest analysis along the unimodal-to-heteromodal principal gradient revealed maximal activation for the convergent cue condition at the heteromodal end, corresponding to the DMN. Our findings are consistent with the view that regions of DMN support states of information integration that constrain ongoing cognition and provide a framework for understanding the location of these effects at the heteromodal end of the principal gradient.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.