Evidence map›Paper›PMID 32522291›Full record

ArticleJournal of nanobiotechnology2020

X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system.

Xuefan Gu, Chao Shen, Hua Li, Ewa M Goldys, Wei Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Pure Organic AIE Nanoscintillator for X-ray Mediated Type I and Type II Photodynamic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  6. Article
  7. Innovative strategies for photodynamic therapy against hypoxic tumor.Asian journal of pharmaceutical sciences · 2023
    Review
  8. Review
  9. Article
  10. Smart FeInternational journal of nanomedicine · 2022
    Article
  11. Review
  12. Review
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Xuefan GuCollege of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, 710065, China.
Chao ShenFaculty of Science and Engineering, Macquarie University, Sydney, NSW, 2109, Australia.
Hua LiCollege of Chemistry and Chemical Engineering, Xi'an Shiyou University, Xi'an, 710065, China.
Ewa M GoldysARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, NSW, 2052, Australia. e.goldys@unsw.edu.au.
Wei DengARC Centre of Excellence for Nanoscale Biophotonics, Graduate School of Biomedical Engineering, University of New South Wales, Kensington, NSW, 2052, Australia. wei.deng@unsw.edu.au.
UNSW Sydney · AUMacquarie University · AUXi'an Shiyou University · CN

Funding

Centre of Excellence scheme from the Australian Research Council CE140100003Ideas Grant from Australian NHMRC GNT1181889National Natural Science Foundation of China 21505103National Natural Science Foundation of China 21675123National Natural Science Foundation of China 21775118Natural Science Foundation of Shaanxi Province 2018JM2018
6 · The paper itself

Abstract

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

Indexed as

GoldLiposomesMitochondriaPhotochemotherapyApoptosisHCT116 CellsHumansMembrane Potential, MitochondrialMetal NanoparticlesSinglet OxygenX-RaysGoldLiposomesSinglet OxygenGold nanoparticlesLiposomeMitochondria-targetedPhotodynamic therapyX-ray

Identifiers

PMID32522291
PMCPMC7288491
OpenAlexW3034008443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.