ArticleParasites & vectors2020
Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The anti-Trypanosoma activities of medicinal plants: A systematic review of the literature.Veterinary medicine and science · 2022Pooled it
- Phytochemical Characterization and Evaluation of the Anticholinesterase and Anti-Life (Basel, Switzerland) · 2026Article
- Integrating Molecular Similarity and AlphaFold-Based Structural Alignment for Target Discovery inPharmaceuticals (Basel, Switzerland) · 2026Article
- Haemanthidine-Containing Alkaloid Fraction fromACS omega · 2026Article
- Antiparasitic Activity of Narciclasine and Evaluation of Its Effects on Plasma Membrane and Mitochondria ofACS omega · 2025Article
- Identification of novel compounds againstComputational and structural biotechnology journal · 2025Article
- Chemical and Biological Aspects of Different Species of the GenusMolecules (Basel, Switzerland) · 2023Article
- The Antioxidant and Proapoptotic Effects ofPlants (Basel, Switzerland) · 2023Article
- Development and Application of an Assay to Evaluate the Anti-Parasitic Effect of Humoral Responses againstMicroorganisms · 2023Article
- Antiparasitic Activity ofMicroorganisms · 2023Article
- State-of-the-Art in the Drug Discovery Pathway for Chagas Disease: A Framework for Drug Development and Target Validation.Research and reports in tropical medicine · 2023Review
- Alkaloid Composition and Biological Activities of the Amaryllidaceae SpeciesPlants (Basel, Switzerland) · 2022Article
- Article
- Identification of compounds with activity againstFrontiers in cellular and infection microbiology · 2022Article
- Article
- In Vitro Anti-Plants (Basel, Switzerland) · 2021Article
- Novel Purine Chemotypes with Activity againstPharmaceuticals (Basel, Switzerland) · 2021Article
- Amaryllidaceae plants: a potential natural resource for the treatment of Chagas disease.Parasites & vectors · 2021Article
- Identification ofMicroorganisms · 2021Article
- Anti-International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundChagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that affects ~7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side effects and limited efficacy at the chronic stage. Natural products provide a pool of diversity structures to lead the chemical synthesis of novel molecules for this purpose. Herein we analyzed the anti-T. cruzi activity of nine alkaloids derived from plants of the family Amaryllidaceae.
methodsThe activity of each alkaloid was assessed by means of an anti-T. cruzi phenotypic assay. We further evaluated the compounds that inhibited parasite growth on two distinct cytotoxicity assays to discard those that were toxic to host cells and assure parasite selectivity.
resultsWe identified a single compound (hippeastrine) that was selectively active against the parasite yielding selectivity indexes of 12.7 and 35.2 against Vero and HepG2 cells, respectively. Moreover, it showed specific activity against the amastigote stage (IC
conclusionsResults reported here suggest that natural products are an interesting source of new compounds for the development of drugs against Chagas disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.