Evidence map›Paper›PMID 32522280›Full record

ArticleBMC medicine2020

Maternal iodine status, intrauterine growth, birth outcomes and congenital anomalies in a UK birth cohort.

Charles Jonathan Peter Snart, Diane Erin Threapleton, Claire Keeble, Elizabeth Taylor, Dagmar Waiblinger, Stephen Reid, Nisreen A Alwan, Dan Mason, Rafaq Azad, Janet Elizabeth Cade and 11 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03552341 (Assessing Iodine Status and Associated Health Outcomes in British Women During Pregnancy), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03552341 completednot on this map

Assessing Iodine Status and Associated Health Outcomes in British Women During Pregnancy

TypeobservationalSponsorUniversity of LeedsRan2016 to 2019Enrolled246ConditionsCognitive Developmental Delay, Birth WeightArmsMaternal iodine status
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Review
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  9. Circulating trace elements for the prediction of preeclampsia and small for gestational age babies.Metabolomics : Official journal of the Metabolomic Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Charles Jonathan Peter SnartLeeds Institute of Cardiovascular & Metabolic Medicine, LIGHT Laboratories, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
Diane Erin ThreapletonLeeds Institute of Cardiovascular & Metabolic Medicine, LIGHT Laboratories, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
Claire KeebleLeeds Institute for Data Analytics, University of Leeds, Leeds, LS2 9JT, UK.
Elizabeth TaylorLeeds Institute of Cardiovascular & Metabolic Medicine, LIGHT Laboratories, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
Dagmar WaiblingerBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK.
Stephen ReidEarth Surface Science Institute, School of Earth and Environment, University of Leeds, Leeds, LS2 9JT, UK.
Nisreen A AlwanSchool of Primary Care and Population Sciences, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK.
Dan MasonBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK.
Rafaq AzadBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK.
Janet Elizabeth CadeNutritional Epidemiology Group, School of Food Science & Nutrition, University of Leeds, Leeds, LS2 9JT, UK.
Nigel A B SimpsonDivision of Women's and Children's Health, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
Sarah MeadowsElsie Widdowson Laboratory, University of Cambridge, Cambridge, CB1 9NL, UK.
Amanda McKillionElsie Widdowson Laboratory, University of Cambridge, Cambridge, CB1 9NL, UK.
Gillian SantorelliBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK.
Amanda H WatermanSchool of Psychology, University of Leeds, Leeds, LS2 9JT, UK.
Michael ZimmermannLaboratory for Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, 8092, Zürich, Switzerland.
Paul M StewartFaculty of Medicine and Health, University of Leeds, Leeds, LS2 9JT, UK.
John WrightBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, BD9 6RJ, UK.
Mark Mon-WilliamsSchool of Psychology, University of Leeds, Leeds, LS2 9JT, UK.
Darren Charles GreenwoodLeeds Institute of Cardiovascular & Metabolic Medicine, LIGHT Laboratories, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK. D.C.Greenwood@leeds.ac.uk.
Laura J HardieLeeds Institute of Cardiovascular & Metabolic Medicine, LIGHT Laboratories, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK. L.J.Hardie@leeds.ac.uk.
University of Leeds · GBBradford Teaching Hospitals NHS Foundation Trust · GBETH Zurich · CHMRC Epidemiology Unit · GBNIHR Southampton Biomedical Research Centre · GBUniversity of Cambridge · GB

Funding

National Institute for Health Research (UK) PR-R10-0514-11004
6 · The paper itself

Abstract

backgroundSevere iodine insufficiency in pregnancy has significant consequences, but there is inadequate evidence to indicate what constitutes mild or moderate insufficiency, in terms of observed detrimental effects on pregnancy or birth outcomes. A limited number of studies have examined iodine status and birth outcomes, finding inconsistent evidence for specific outcomes.

methodsMaternal iodine status was estimated from spot urine samples collected at 26-28 weeks' gestation from 6971 mothers in the Born in Bradford birth cohort. Associations with outcomes were examined for both urinary iodine concentration (UIC) and iodine-to-creatinine ratio (I:Cr). Outcomes assessed included customised birthweight (primary outcome), birthweight, small for gestational age (SGA), low birthweight, head circumference and APGAR score.

resultsThere was a small positive association between I:Cr and birthweight in adjusted analyses. For a typical participant, the predicted birthweight centile at the 25th percentile of I:Cr (59 μg/g) was 2.7 percentage points lower than that at the 75th percentile of I:Cr (121 μg/g) (99% confidence interval (CI) 0.8 to 4.6), birthweight was predicted to be 41 g lower (99% CI 13 to 69) and the predicted probability of SGA was 1.9 percentage points higher (99% CI 0.0 to 3.7). There was no evidence of associations using UIC or other birth outcomes, including stillbirth, preterm birth, ultrasound growth measures or congenital anomalies.

conclusionLower maternal iodine status was associated with lower birthweight and greater probability of SGA. Whilst small, the effect size for lower iodine on birthweight is comparable to environmental tobacco smoke exposure. Iodine insufficiency is avoidable, and strategies to avoid deficiency in women of reproductive age should be considered.

trial registrationClinicalTrials.gov NCT03552341. Registered on June 11, 2018.

Indexed as

AdultBirth WeightCongenital AbnormalitiesFemaleFetal Growth RetardationHumansInfant, NewbornIodineMaleMothersPregnancyPregnancy OutcomeUnited KingdomIodineBirthweightInsufficiencyIodinePregnancySGA

Identifiers

PMID32522280
PMCPMC7288513
OpenAlexW3033379407

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.