Evidence map›Paper›PMID 32522213›Full record

ArticleJournal of cardiothoracic surgery2020

Normoxic re-oxygenation ameliorates end-organ injury after cardiopulmonary bypass.

Yun-Wen Peng, Terry Major, Azmath Mohammed, Kristopher B Deatrick, John R Charpie

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiothoracic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yun-Wen PengDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, 1540 East Hospital Drive, 11-740 C.S. Mott Children's Hospital, Ann Arbor, MI, 48109-4204, USA.
Terry MajorDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Azmath MohammedDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Kristopher B DeatrickDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
John R CharpieDivision of Pediatric Cardiology, Department of Pediatrics, University of Michigan Medical School, 1540 East Hospital Drive, 11-740 C.S. Mott Children's Hospital, Ann Arbor, MI, 48109-4204, USA. jcharpie@med.umich.edu.ORCID http://orcid.org/0000-0003-1722-525X
University of Michigan · US

Funding

Caden's Full Throttle Event NA
6 · The paper itself

Abstract

backgroundIn a rabbit model of cardiopulmonary bypass (CPB) and cardioplegic arrest, we previously showed that hyperoxic myocardial reperfusion was associated with increased left ventricular (LV) systolic dysfunction and myocardial injury compared with normoxic reperfusion. The aim of this study was to evaluate in our experimental model the impact of post-CPB reperfusion conditions on other organs potentially vulnerable to ischemic injury such as the brain and kidney.

methodsAfter 60 min of CPB, aortic cross-clamp, and cold cardioplegic arrest, rabbits were reperfused under hyperoxic or normoxic conditions for 120 min. Left ventricular systolic contractility (LV + dP/dt) and diastolic relaxation (LV -dP/dt) were continuously recorded, and end-organ injury was assessed by measuring circulating biomarkers specific for kidney (cystatin C and creatinine) and brain injury [S100B and neuron specific enolase (NSE)]. At completion of the protocol, kidney and brain tissues were harvested for measuring oxidant stress (OS), inflammation and apoptosis.

resultsFollowing aortic cross-clamp removal, rabbits exposed to normoxic reperfusion demonstrated preserved LV systolic and diastolic function compared with hyperoxic reperfusion (LV + dP/dt: 70 ± 14% of pre-CPB vs. 36 ± 21%, p = 0.018; LV -dP/dt: 72 ± 36% of pre-CPB vs. 33 ± 20%, p = 0.023). Similarly, CPB increased plasma creatinine, S100B and NSE that were significantly attenuated by normoxic reperfusion compared with hyperoxic reperfusion (creatinine: 4.0 ± 0.5 vs. 7.1 ± 0.8 mg/dL, p = 0.004; S100B: 4.0 ± 0.8 vs. 6.7 ± 1.0 ng/mL, p = 0.047; NSE: 57.7 ± 6.8 vs. 101.3 ± 16.1 pg/mL, p = 0.040). Furthermore, both kidney and brain tissues showed increased mRNA expression and activation of pathways for OS, inflammation, and apoptosis, that were reduced under normoxic compared with hyperoxic conditions.

conclusionsNormoxic reperfusion ameliorates cardiac, renal and neural injury compared with hyperoxic reperfusion in an in vivo animal model of CPB and cardioplegic arrest. This protective effect of normoxic reperfusion may be due to a reduction in signaling pathways for OS, inflammation, and apoptosis.

Indexed as

AnimalsApoptosisBiomarkersBrainBrain IschemiaCardiopulmonary BypassCreatinineCystatin CHeart Arrest, InducedInflammationKidneyKidney DiseasesMaleOxidative StressOxygenPhosphopyruvate HydrataseBiomarkersCreatinineCystatin COxygenPhosphopyruvate HydrataseRNA, MessengerS100B protein, humanS100 Calcium Binding Protein beta SubunitBrain injuryCardioplegic arrestCardiopulmonary bypass/hyperoxiaNormoxiaRenal injuryReperfusion

Identifiers

PMID32522213
PMCPMC7285475
OpenAlexW3033537753

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.