Evidence map›Paper›PMID 32522127›Full record

ReviewRNA biology2020

New twists on long noncoding RNAs: from mobile elements to motile cancer cells.

Tuan M Nguyen, Sumayya Alchalabi, Adewunmi Oluwatoyosi, Ali S Ropri, Jason I Herschkowitz, Jeffrey M Rosen

Open access · bronzeAbstract readReview
In one paragraph

Review in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tuan M NguyenHarvard Medical School Initiative for RNA Medicine, Harvard Medical School , Boston, MA, USA.ORCID 0000-0003-4879-3962
Sumayya AlchalabiDepartment of Biomedical Sciences, Cancer Research Center, University at Albany, SUNY , Rensselaer, NY, USA.ORCID 0000-0001-6075-9631
Adewunmi OluwatoyosiDepartment of Molecular & Cellular Biology, Baylor College of Medicine , Houston, TX, USA.ORCID 0000-0002-0664-0194
Ali S RopriDepartment of Biomedical Sciences, Cancer Research Center, University at Albany, SUNY , Rensselaer, NY, USA.ORCID 0000-0001-6159-1543
Jason I HerschkowitzDepartment of Biomedical Sciences, Cancer Research Center, University at Albany, SUNY , Rensselaer, NY, USA.ORCID 0000-0003-1047-021X
Jeffrey M RosenDepartment of Molecular & Cellular Biology, Baylor College of Medicine , Houston, TX, USA.ORCID 0000-0002-6637-844X
University at Albany, State University of New York · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · US

Funding

MALAT1 lncRNA as a Therapeutic Target in Triple Negative Breast CancerR01CA016303 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSEN, JEFFREY MARK · 1985 to 2022
$8.1M
HORMONAL REGULATION OF BREAST CANCERR37CA016303 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ROSEN, JEFFREY MARK · 1989 to 2011
$7.3M
NCI NIH HHS R01 CA016303NCI NIH HHS R37 CA016303
6 · The paper itself

Abstract

The purpose of this review is to highlight several areas of lncRNA biology and cancer that we hope will provide some new insights for future research. These include the relationship of lncRNAs and the epithelial to mesenchymal transition (EMT) with a focus on transcriptional and alternative splicing mechanisms and mRNA stability through miRNAs. In addition, we highlight the potential role of enhancer e-lncRNAs, the importance of transposable elements in lncRNA biology, and finally the emerging area of using antisense oligonucleotides (ASOs) and small molecules to target lncRNAs and their therapeutic implications.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsCell MovementDisease SusceptibilityDNA Transposable ElementsEnhancer Elements, GeneticEpithelial-Mesenchymal TransitionHumansMicroRNAsNeoplasmsProtein BindingRNA, Long NoncodingRNA, MessengerRNA Processing, Post-TranscriptionalRNA SplicingRNA StabilityDNA Transposable ElementsMicroRNAsRNA, Long NoncodingRNA, MessengerTranscription FactorsEMTlncRNAstransposable elements

Identifiers

PMID32522127
PMCPMC7567495
OpenAlexW3033539806

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.