Evidence map›Paper›PMID 32522007›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

SR-BI (Scavenger Receptor BI), Not LDL (Low-Density Lipoprotein) Receptor, Mediates Adrenal Stress Response-Brief Report.

Misa Ito, Xiang Ye, Qian Wang, Ling Guo, Dan Hao, Deborah Howatt, Alan Daugherty, Lei Cai, Ryan Temel, Xiang-An Li

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. The Role of Scavenger Receptor BI in Sepsis.International journal of molecular sciences · 2024
    Review
  6. Effects of Environmental Noise Stress on Mouse Metabolism.International journal of molecular sciences · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Misa ItoFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Xiang YeFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Qian WangFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Ling GuoFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Dan HaoFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Deborah HowattFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Alan DaughertyFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Lei CaiFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Ryan TemelFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
Xiang-An LiFrom the Saha Cardiovascular Research Center (M.I., X.Y., Q.W., L.G., D. Hao, D. Howatt, A.D., L.C., R.T., X.-A.L.), University of Kentucky College of Medicine, Lexington.
University of Kentucky · US

Funding

Synthetic HDL_a potential sepsis therapyR01GM113832 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN, SCHWENDEMAN, ANNA · 2015 to 2019
$3.0M
Mechanism of adrenal insufficiency as a risk factor for sepsisR01GM121796 · NIGMS · UNIVERSITY OF KENTUCKY · PI LI, XIANG-AN · 2017 to 2020
$1.2M
HDL as a therapeutic target for sepsisI01BX004639 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI LI, XIANG-AN · 2020 to 2023
–
BLRD VA I01 BX004639NIGMS NIH HHS R01 GM113832NIGMS NIH HHS R01 GM121796
6 · The paper itself

Abstract

objectiveAdrenal gland secretes stress-induced glucocorticoids (iGCs) to coping with stress. Previous study showed that SR-BI (scavenger receptor BI) null (SR-BI

conclusionsSR-BI

Indexed as

Adrenocorticotropic HormoneAnimalsGlucocorticoidsLipoproteins, LDLMiceMice, Inbred C57BLReceptors, LDLScavenger Receptors, Class BStress, PsychologicalAdrenocorticotropic HormoneGlucocorticoidsLipoproteins, LDLReceptors, LDLScarb1 protein, mouseScavenger Receptors, Class Badrenocorticotropic hormoneapolipoproteins Bglucocorticoidslipoproteinsmicescavenger receptor type B class Isepsis

Identifiers

PMID32522007
PMCPMC7526689
OpenAlexW3033797426

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.