Evidence map›Paper›PMID 32521766›Full record

ArticleCells2020

Chromatin Trapping of Factors Involved in DNA Replication and Repair Underlies Heat-Induced Radio- and Chemosensitization.

Artem V Luzhin, Bogdan Avanesyan, Artem K Velichko, Victoria O Shender, Natalia Ovsyannikova, Georgij P Arapidi, Polina V Shnaider, Nadezhda V Petrova, Igor I Kireev, Sergey V Razin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Artem V LuzhinInstitute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.ORCID 0000-0002-8859-5306
Bogdan AvanesyanInstitute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.
Artem K VelichkoInstitute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.
Victoria O ShenderCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Natalia OvsyannikovaA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Georgij P ArapidiCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Polina V ShnaiderCenter for Precision Genome Editing and Genetic Technologies for Biomedicine, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, 119435 Moscow, Russia.
Nadezhda V PetrovaInstitute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.
Igor I KireevA.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.
Sergey V RazinInstitute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.
Omar L KantidzeInstitute of Gene Biology Russian Academy of Science, 119334 Moscow, Russia.ORCID 0000-0002-7507-7307
Institute of Gene Biology · RULomonosov Moscow State University · RUFederal Medical-Biological Agency · RUInstitute of Bioorganic Chemistry · RUMoscow Institute of Physics and Technology · RUSechenov University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperthermia has been used as an adjuvant treatment for radio- and chemotherapy for decades. In addition to its effects on perfusion and oxygenation of cancer tissues, hyperthermia can enhance the efficacy of DNA-damaging treatments such as radiotherapy and chemotherapy. Although it is believed that the adjuvant effects are based on hyperthermia-induced dysfunction of DNA repair systems, the mechanisms of these dysfunctions remain elusive. Here, we propose that elevated temperatures can induce chromatin trapping (

Indexed as

DNA RepairDNA ReplicationHot TemperatureChromatinDNADNA DamageHEK293 CellsHeLa CellsHumansNuclear ProteinsPoly Adenosine Diphosphate RibosePoly(ADP-ribose) PolymerasesChromatinDNANuclear ProteinsOkazaki fragmentsPoly Adenosine Diphosphate RibosePoly(ADP-ribose) PolymeraseschromatinDNA repairDNA replicationhyperthermiaPARP

Identifiers

PMID32521766
PMCPMC7349668
OpenAlexW3033338484

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.