Evidence map›Paper›PMID 32521743›Full record

ArticleBiomolecules2020

Fibrillization of 40-Residue β-Amyloid Peptides in Membrane-Like Environments Leads to Different Fibril Structures and Reduced Molecular Polymorphisms.

Qinghui Cheng, Zhi-Wen Hu, Yuto Tobin-Miyaji, Amy E Perkins, Terrence Deak, Wei Qiang

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Membrane-assisted Aβ40 aggregation pathways.Cell reports. Physical science · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. In-cellBiophysical chemistry · 2023
    Article
  8. Membrane-induced tau amyloid fibrils.Communications biology · 2023
    Article
  9. Molecular mechanisms of amyloid disaggregation.Journal of advanced research · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qinghui ChengDepartment of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902, USA.
Zhi-Wen HuDepartment of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902, USA.
Yuto Tobin-MiyajiDepartment of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902, USA.
Amy E PerkinsDepartment of Psychology, State University of New York at Binghamton, Binghamton, NY 13902, USA.
Terrence DeakDepartment of Psychology, State University of New York at Binghamton, Binghamton, NY 13902, USA.
Wei QiangDepartment of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902, USA.
Binghamton University · US

Funding

Molecular Structural Basis of Non-specific Neuronal Membrane Disruption Induced by Early-Stage Beta-Amyloid Peptide AggregationR01GM125853 · NIGMS · STATE UNIVERSITY OF NY,BINGHAMTON · PI Wei Qiang · 2018 to 2026
$2.5M
Neuroinflammation and social behavior across the lifespanR01AG043467 · NIA · STATE UNIVERSITY OF NY,BINGHAMTON · PI DEAK, TERRENCE · 2014 to 2018
$2.3M
NIA NIH HHS R01 AG043467NIGMS NIH HHS R01 GM125853
6 · The paper itself

Abstract

The molecular-level polymorphism in β-Amyloid (Aβ) fibrils have recently been considered as a pathologically relevant factor in Alzheimer's disease (AD). Studies showed that the structural deviations in human-brain-seeded Aβ fibrils potentially correlated with the clinical histories of AD patients. For the 40-residue Aβ (Aβ

Indexed as

Amyloid beta-PeptidesAnimalsCell MembraneKineticsMaleNuclear Magnetic Resonance, BiomolecularParticle SizeProtein ConformationRatsRats, Inbred F344Surface PropertiesAmyloid beta-Peptidesbiological membranesstructural polymorphismssynaptic plasma membranesβ-amyloid fibrils

Identifiers

PMID32521743
PMCPMC7356566
OpenAlexW3032964266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.