Evidence map›Paper›PMID 32521742›Full record

ArticlePharmaceutics2020

Elucidation of Inverse Agonist Activity of Bilastine.

Hiroyuki Mizuguchi, Tomoharu Wakugawa, Hisato Sadakata, Seiichiro Kamimura, Mai Takemoto, Tomomi Nakagawa, Masami Yabumoto, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Ocular Biodistribution of Once-Daily 0.6% Bilastine Eye Drops Reveals Highest Levels in Conjunctiva Up to 24 h Postadministration.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2022
    Article
  5. Differential Regulation of Bilastine Affinity for Human Histamine HInternational journal of molecular sciences · 2021
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hiroyuki MizuguchiLaboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka 584-8540, Japan.
Tomoharu WakugawaDepartment of Molecular Pharmacology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8505, Japan.
Hisato SadakataTIMELAPS VISION INC., Saitama 353-0004, Japan.
Seiichiro KamimuraDepartment of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8505, Japan.
Mai TakemotoLaboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka 584-8540, Japan.
Tomomi NakagawaLaboratory of Pharmacology Faculty of Pharmacy Osaka Ohtani University, Osaka 584-8540, Japan.
Masami YabumotoMedical Corporation Kinshukai, Osaka 558-0011, Japan.
Yoshiaki KitamuraDepartment of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8505, Japan.
Noriaki TakedaDepartment of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8505, Japan.
Hiroyuki FukuiDepartment of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8505, Japan.
Tokushima University · JPOsaka Ohtani University · JPKishokai Medical Corporation · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

H

Indexed as

H1-antihistamineshistamine H1 receptor gene expressioninositol phosphates accumulationinverse agonisttime-laps Ca2+ imaging

Identifiers

PMID32521742
PMCPMC7355758
OpenAlexW3033082253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.