Evidence map›Paper›PMID 32521725›Full record

ReviewInternational journal of molecular sciences2020

Endometrial Decidualization: The Primary Driver of Pregnancy Health.

Shu-Wing Ng, Gabriella A Norwitz, Mihaela Pavlicev, Tamara Tilburgs, Carlos Simón, Errol R Norwitz

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 6 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 6 syntheses or guidelines pooled it, 367 citations in OpenAlex.

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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Shu-Wing NgDepartment of Obstetrics & Gynecology, Tufts University School of Medicine, Boston, MA 02111, USA.
Gabriella A NorwitzSchool of Public Health, University of Michigan, Ann Arbor, MI 48109, USA.
Mihaela PavlicevDepartment of Theoretical Biology, University of Vienna, 1010 Vienna, Austria.ORCID 0000-0001-8439-9351
Tamara TilburgsDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA.
Carlos SimónDepartment of Obstetrics & Gynecology, Valencia University and INCLIVA, 46010 Valencia, Spain.
Errol R NorwitzDepartment of Obstetrics & Gynecology, Tufts University School of Medicine, Boston, MA 02111, USA.
Tufts University · USBeth Israel Deaconess Medical Center · USCincinnati Children's Hospital Medical Center · USUniversity of Michigan · USUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interventions to prevent pregnancy complications have been largely unsuccessful. We suggest this is because the foundation for a healthy pregnancy is laid prior to the establishment of the pregnancy at the time of endometrial decidualization. Humans are one of only a few mammalian viviparous species in which decidualization begins during the latter half of each menstrual cycle and is therefore independent of the conceptus. Failure to adequately prepare (decidualize) the endometrium hormonally, biochemically, and immunologically in anticipation of the approaching blastocyst-including the downregulation of genes involved in the pro- inflammatory response and resisting tissue invasion along with the increased expression of genes that promote angiogenesis, foster immune tolerance, and facilitate tissue invasion-leads to abnormal implantation/placentation and ultimately to adverse pregnancy outcome. We hypothesize, therefore, that the primary driver of pregnancy health is the quality of the soil, not the seed.

Indexed as

AnimalsAutocrine CommunicationBiomarkersDeciduaEmbryo ImplantationEndometriumFemaleGene Expression RegulationHumansParacrine CommunicationPlacentationPregnancyPregnancy ComplicationsPregnancy OutcomeBiomarkersadverse pregnancy outcomedecidualizationendometriumpreconception

Identifiers

PMID32521725
PMCPMC7312091
OpenAlexW3033214241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.