Evidence map›Paper›PMID 32521695›Full record

ReviewJournal of clinical medicine2020

Diabetic Foot Infections: The Diagnostic Challenges.

Chiara Lauri, Antonio Leone, Marco Cavallini, Alberto Signore, Laura Giurato, Luigi Uccioli

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Diagnostic imaging of the diabetic foot: an EANM evidence-based guidance.European journal of nuclear medicine and molecular imaging · 2024
    Guideline
  3. Pooled it
  4. Article
  5. Article
  6. Use of thermal imaging in the detection of the diabetic foot- review.Reviews in endocrine & metabolic disorders · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Nanozymes for Accelerating the Foot Wound Healing: A Review.International journal of nanomedicine · 2025
    Review
  11. Review
  12. RTP4 Enhances Corneal HSV-1 Infection in Mice With Type 2 Diabetes Mellitus.Investigative ophthalmology & visual science · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The Role of Serial Radiographs in Diagnosing Diabetic Foot Bone Osteomyelitis.Mediterranean journal of hematology and infectious diseases · 2022
    Article
  18. Review
  19. Article
  20. Pathophysiology and Molecular Imaging of Diabetic Foot Infections.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chiara LauriNuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0002-0314-5059
Antonio LeoneDepartment of Radiological and Haematological Sciences, Fondazione Policlinico Universitario A. Gemelli, ISCSS-Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Marco CavalliniWound Care Department of Medical-Surgical Sciences and of Translational Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.
Alberto SignoreNuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, "Sapienza" University of Rome, 00161 Rome, Italy.ORCID 0000-0001-8923-648X
Laura GiuratoDiabetic Foot Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Luigi UccioliDiabetic Foot Unit, Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.ORCID 0000-0001-5087-2091

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot infections (DFIs) are severe complications of long-standing diabetes, and they represent a diagnostic challenge, since the differentiation between osteomyelitis (OM), soft tissue infection (STI), and Charcot's osteoarthropathy is very difficult to achieve. Nevertheless, such differential diagnosis is mandatory in order to plan the most appropriate treatment for the patient. The isolation of the pathogen from bone or soft tissues is still the gold standard for diagnosis; however, it would be desirable to have a non-invasive test that is able to detect, localize, and evaluate the extent of the infection with high accuracy. A multidisciplinary approach is the key for the correct management of diabetic patients dealing with infective complications, but at the moment, no definite diagnostic flow charts still exist. This review aims at providing an overview on multimodality imaging for the diagnosis of DFI and to address evidence-based answers to the clinicians when they appeal to radiologists or nuclear medicine (NM) physicians for studying their patients.

Indexed as

[18F]FDG PET/CTdiabetic footimaginginfectionMRIWBC scintigraphy

Identifiers

PMID32521695
PMCPMC7355769

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.