Evidence map›Paper›PMID 32521645›Full record

ReviewCancers2020

Diffusion-Weighted Imaging in Oncology: An Update.

Carmelo Messina, Rodolfo Bignone, Alberto Bruno, Antonio Bruno, Federico Bruno, Marco Calandri, Damiano Caruso, Pietro Coppolino, Riccardo De Robertis, Francesco Gentili and 6 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 5 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 5 syntheses or guidelines pooled it, 182 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Deep learning in MRI-guided radiation therapy: A systematic review.Journal of applied clinical medical physics · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Article
  7. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Early Detection of Cell Death Using Transmembrane Water Exchange Magnetic Resonance Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Review
  15. Article
  16. Review
  17. Multi-center diffusion-weighted MRI validation for 0.35T MR-Linac.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026
    Article
  18. Article
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 1 country.

Carmelo MessinaIRCCS Istituto Ortopedico Galeazzi, 20161 Milano, Italy.
Rodolfo BignoneRadiology Unit, University of Palermo, 90127 Palermo, Italy.
Alberto BrunoRadiology Unit, University of Palermo, 90127 Palermo, Italy.
Antonio BrunoDept. of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, S.Orsola-Malpighi Hospital, 40126 Bologna, Italy.
Federico BrunoDepartment of Biotechnology and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Marco CalandriRadiology Unit, A.O.U. San Luigi Gonzaga di Orbassano, Department of Oncology, University of Torino, 10043 Turin, Italy.
Damiano CarusoDepartment of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, Sant'Andrea University Hospital, 00161 Rome, Italy.
Pietro CoppolinoDepartment of Medical Surgical Sciences and Advanced Technologies "G.F. Ingrassia"-Radiology I Unit, University Hospital "Policlinico-Vittorio Emanuele", 95123 Catania, Italy.
Riccardo De RobertisDepartment of Radiology, Ospedale Civile Maggiore, Azienda Ospedaliera Universitaria Integrata Verona, 37134 Verona, Italy.
Francesco GentiliSection of Radiology, Unit of Surgical Sciences, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.
Irene GrazziniDepartment of Radiology, Section of Neuroradiology, San Donato Hospital, 52100 Arezzo, Italy.
Raffaele NatellaDepartment of Precision Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Paola ScaliseDepartment of Diagnostic Imaging, Pisa University Hospital, 56124 Pisa, Italy.
Antonio BarileDepartment of Biotechnology and Applied Clinical Sciences, University of L'Aquila, 67100 L'Aquila, Italy.
Roberto GrassiDepartment of Precision Medicine, University of Campania "L. Vanvitelli", 80138 Naples, Italy.
Domenico AlbanoIRCCS Istituto Ortopedico Galeazzi, 20161 Milano, Italy.ORCID 0000-0001-7989-9861
IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of L'Aquila · ITAzienda Ospedaliera Universitaria Integrata Verona · ITAzienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele · ITIstituto Ortopedico Galeazzi · ITOspedale San Donato · ITOspedale San Luigi Gonzaga · ITSapienza University of Rome · ITUniversity of Milan · ITUniversity of Palermo · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, diffusion weighted imaging (DWI) is included in routine magnetic resonance imaging (MRI) protocols for several cancers. The real additive role of DWI lies in the "functional" information obtained by probing the free diffusivity of water molecules into intra and inter-cellular spaces that in tumors mainly depend on cellularity. Although DWI has not gained much space in some oncologic scenarios, this non-invasive tool is routinely used in clinical practice and still remains a hot research topic: it has been tested in almost all cancers to differentiate malignant from benign lesions, to distinguish different malignant histotypes or tumor grades, to predict and/or assess treatment responses, and to identify residual or recurrent tumors in follow-up examinations. In this review, we provide an up-to-date overview on the application of DWI in oncology.

Indexed as

apparent diffusion coefficientcancer imagingdiffusion weighted imagingmagnetic resonance imagingoncologic imaging

Identifiers

PMID32521645
PMCPMC7352852
OpenAlexW3034114378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.