ArticleBipolar disorders2021
Altered frontal cortex functioning in emotion regulation and hopelessness in bipolar disorder.
Article in Bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants.Scientific reports · 2026Trial
- Chronotherapeutic intervention targeting emotion regulation brain circuitry, symptoms, and suicide risk in adolescents and young adults with bipolar disorder: a pilot randomised trial.BMJ mental health · 2025Trial
- Alexithymia and self-harm in depressed adolescents: the mediating role of resting-state functional connectivity of the ventral hippocampal-fusiform gyrus.Annals of general psychiatry · 2026Article
- DEDUCE: statistical inference on disease-associated genes uncovers tissue-disease associations.NAR genomics and bioinformatics · 2025Article
- Abnormal grey matter in identifying primary intravaginal anejaculation patients from healthy controls: a voxel-based morphometry analysis.Sexual medicine · 2025Article
- Maladaptive Thinking Styles and Suicide Cognitions: Serial Mediation of Difficulties in Emotion Regulation and Loneliness.The Psychiatric quarterly · 2025Article
- Polygenic overlap between subjective well-being and psychiatric disorders and cross-ancestry validation.Nature human behaviour · 2025Article
- Machine learning-based assessment of morphometric abnormalities distinguishes bipolar disorder and major depressive disorder.Neuroradiology · 2025Article
- Magnetic resonance imaging of regional gray matter volume in persons who died by suicide.Molecular psychiatry · 2025Article
- Clinical and electrophysiological correlates of hopelessness in the context of suicide riskEuropean neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2024Article
- Classification of bipolar disorders using the multilayer modularity in dynamic minimum spanning tree from resting state fMRI.Cognitive neurodynamics · 2023Article
- Perceiving visual negative stimuli in schizophrenia and bipolar disorder: Meta-analytic evidence of a common altered thalamic-parahippocampal-basal ganglia circuit.Neuroimage. Reports · 2023Article
- Pushing the Frontiers: Optogenetics for Illuminating the Neural Pathophysiology of Bipolar Disorder.International journal of biological sciences · 2023Review
- The longitudinal trajectory of emotion regulation and associated neural activity in patients with bipolar disorder: A prospective fMRI study.Acta psychiatrica Scandinavica · 2022Article
- The associations between suicide-related behaviors, prefrontal dysfunction in emotional cognition, and personality traits in mood disorders.Scientific reports · 2022Article
- Graph theory analysis of whole brain functional connectivity to assess disturbances associated with suicide attempts in bipolar disorder.Translational psychiatry · 2022Article
- Mapping structural covariance networks in children and adolescents with post-traumatic stress disorder after earthquake.Frontiers in psychiatry · 2022Article
- Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis.Frontiers in psychiatry · 2021Article
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12 authors.
Funding
Abstract
objectivesEmotion regulation difficulties precipitate and exacerbate acute mood symptoms in individuals with bipolar disorder (BD), and contribute to suicidal behavior. However, few studies have examined regional brain responses in explicit emotion regulation during acute BD mood states, or hopelessness, a major suicide risk factor. We assessed brain responses during explicit emotion regulation, and their relationship with hopelessness, in acutely symptomatic and euthymic individuals with BD.
methodsFunctional MRI data were obtained from individuals with BD who were either in acute negative (BD-A; n = 24) or euthymic (BD-E; n = 24) mood states, and from healthy volunteers (HV; n = 55), while participants performed a paradigm that instructed them to downregulate their responses to fearful (EmReg-Fear) and happy (EmReg-Happy) facial stimuli. Emotion regulation-related differences in brain responses during negative and euthymic BD states, as well as their associations with negative affective symptoms (hopelessness and depression), were examined.
resultsDecreased responses were observed in ventral and dorsal frontal regions, including medial orbitofrontal (mOFC) and dorsal anterior cingulate cortices, during EmReg-Fear across symptomatic and euthymic states in participants with BD relative to HVs. The lowest responses were observed in the BD-A group. Across BD participants, negative associations were observed between mOFC responses and hopelessness, particularly due to loss of motivation. Differences were not significant during EmReg-Happy.
conclusionsLesser emotion regulation-related ventral and dorsal frontal engagement in BD could represent a trait abnormality that worsens during acute negative states. The reduced mOFC engagement in BD during explicit regulation of negative emotions may contribute to hopelessness particularly in the context of diminished motivation.
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