Evidence map›Paper›PMID 32521537›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Elevated fatty acid amide hydrolase in the prefrontal cortex of borderline personality disorder: a [

Nathan J Kolla, R Mizrahi, K Karas, C Wang, R M Bagby, S McMain, A I Simpson, P M Rusjan, R Tyndale, S Houle and 1 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Research Review: What we have learned about the endocannabinoid system in developmental psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Association ofCell journal · 2023
    Article
  10. Genes · 2023
    Review
  11. Article
  12. Article
  13. Borderline Personality Disorder: Updates in a Postpandemic World.Focus (American Psychiatric Publishing) · 2022
    Review
  14. Combinatorial approaches for treating neuropsychiatric social impairment.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Review
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Nathan J KollaCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada. nathan.kolla@camh.ca.
R MizrahiCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-6667-7928
K KarasCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
C WangCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
R M BagbyCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
S McMainCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
A I SimpsonCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-0478-2583
P M RusjanCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-0075-2918
R TyndaleCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
S HouleCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
I BoileauCentre for Addiction and Mental Health (CAMH), Toronto, ON, Canada.
Centre for Addiction and Mental Health · CA

Funding

Imaging Alterations in Endocannabinoid Metabolism in Clinical High Risk and First Episode PsychosisR01MH113564 · NIMH · MCGILL UNIVERSITY · PI MIZRAHI, ROMINA · 2017 to 2022
$2.2M
Imaging Neuroinflammation in Clinical high risk and SchizophreniaR01MH100043 · NIMH · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI MIZRAHI, ROMINA · 2014 to 2018
$1.6M
Endocannabinoid Metabolism in Cannabis Users: PET Studies with the Novel Probe [1R21DA036024 · NIDA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI BOILEAU, ISABELLE · 2013 to 2014
$295k
CIHR FDN: 154294NIDA NIH HHS DA036024-01NIMH NIH HHS R01 MH100043NIMH NIH HHS R01 MH113564
6 · The paper itself

Abstract

Amygdala-prefrontal cortex (PFC) functional impairments have been linked to emotion dysregulation and aggression in borderline personality disorder (BPD). Fatty acid amide hydrolase (FAAH), the major catabolic enzyme for the endocannabinoid anandamide, has been proposed as a key regulator of the amygdala-PFC circuit that subserves emotion regulation. We tested the hypothesis that FAAH levels measured with [

Indexed as

Borderline Personality DisorderMajor Depressive DisorderAmidohydrolasesFatty Acid Amide HydrolasesHumansMagnetic Resonance ImagingPositron-Emission TomographyPrefrontal CortexAmidohydrolasesFatty Acid Amide Hydrolases

Identifiers

PMID32521537
PMCPMC7608329
OpenAlexW3033044767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.