Evidence map›Paper›PMID 32521478›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2020

Signal enhancement of glutamine and glutathione by single-step spectral editing.

Li An, Maria Ferraris Araneta, Milalynn Victorino, Jun Shen

Abstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Detection ofScientific reports · 2022
    Article
  3. Glutamine Imaging: A New Avenue for Glioma Management.AJNR. American journal of neuroradiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Li AnMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States. Electronic address: li.an@nih.gov.
Maria Ferraris AranetaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Milalynn VictorinoMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.
Jun ShenMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States.

Funding

Magnetic Resonance Spectroscopy and Imaging Studies of Brain FunctionsZIAMH002803 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2009 to 2025
$24.9M
Magnetic Resonance Spectroscopy Core FacilityZICMH002894 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2009 to 2024
$13.5M
MRS and Imaging Studies of Brain FunctionsZ01MH002803 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI SHEN, JUN · 2003 to 2008
$1.8M
Intramural NIH HHS Z01 MH002803Intramural NIH HHS Z99 MH999999
6 · The paper itself

Abstract

A single-step spectral editing approach using an always-on editing pulse was proposed to enhance the signals of strongly coupled spins. Specifically, a single-step spectral editing sequence with an always-on editing pulse applied at 2.12 ppm was used to enhance glutamine (Gln) and glutathione (GSH) signals at TE = 56 ms on a 7 T scanner. Density matrix simulations demonstrated that the current method (TE = 56 ms) led to large signal enhancement of at least 61% for Gln and 51% for GSH compared to a previous single-step method (TE = 106 ms). Monte Carlo simulations showed that the current method reduced noise-originated variations by 31% for Gln and 26% for GSH compared to a previous three-step spectral editing method from which the present method was derived.

Indexed as

Brain ChemistryAdultAlgorithmsFemaleGlutamic AcidGlutamineGlutathioneHumansMagnetic Resonance SpectroscopyMaleMonte Carlo MethodSensitivity and SpecificitySignal-To-Noise RatioGlutamic AcidGlutamineGlutathioneGlutamateGlutamineGlutathioneSpectral editing

Identifiers

PMID32521478
PMCPMC7385909

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.