Evidence map›Paper›PMID 32521436›Full record

ReviewCurrent opinion in neurobiology2020

Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.

William Christopher Risher, Cagla Eroglu

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Brain communications · 2026
    Article
  5. Article
  6. New Molecular Insights on Gabapentin.ACS physical chemistry Au · 2025
    Article
  7. Presynaptic αNeuron · 2025
    Article
  8. Article
  9. Nicotine Motivated Behavior inInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Pathophysiological Roles of Auxiliary Calcium Channel αHandbook of experimental pharmacology · 2023
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

William Christopher RisherDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25705, United States. Electronic address: risherw@marshall.edu.
Cagla ErogluDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, United States; Duke Institute for Brain Sciences (DIBS), Durham, NC 27710, United States; Regeneration Next Initiative, Duke University, Durham, NC 27710, United States.
Duke Medical Center · USMarshall University · US

Funding

Control of Astrocyte Development and Astrocyte-Synapse InteractionsR01NS102237 · NINDS · DUKE UNIVERSITY · PI EROGLU, CAGLA · 2018 to 2022
$1.9M
The Regulation of Synaptic Connectivity and Homeostasis by HuntingtinR01NS096352 · NINDS · DUKE UNIVERSITY · PI EROGLU, CAGLA · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS096352NINDS NIH HHS R01 NS102237
6 · The paper itself

Abstract

Central nervous system function requires the proper formation and function of synapses. The α2δ auxiliary subunits of voltage-gated calcium channels have emerged as regulators of a number of critical events associated with regulation of synaptic function, including channel trafficking and localization, as well as the initial establishment of synaptic structures. In this review, we will discuss some of these recent studies which have uncovered novel mechanisms for α2δ function at the synapse, including the regulation of calcium channel α1 subunit specificity and the promotion of dendritic spine growth. Moreover, we will cover recent advances that have been made in understanding the consequences of aberrant α2δ signaling in injury and disease.

Indexed as

CalciumCalcium ChannelsProtein SubunitsProtein TransportSynapsesCalciumCalcium ChannelsProtein Subunits

Identifiers

PMID32521436
PMCPMC7483897
OpenAlexW3032925347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.