Evidence map›Paper›PMID 32521274›Full record

ArticleCell reports2020

Slow Receptor Binding of the Noncytopathic HIV-2

Miranda Harris, Sneha Ratnapriya, Angela Chov, Héctor Cervera, Alisha Block, Christopher Gu, Nathaniel Talledge, Louis M Mansky, Joseph Sodroski, Alon Herschhorn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Incompletely closed HIV-1Npj viruses · 2025
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  8. Alternative substitutions of N332 in HIV-1bioRxiv : the preprint server for biology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Miranda HarrisDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Sneha RatnapriyaDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Angela ChovDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Héctor CerveraDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Alisha BlockDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Christopher GuDepartment of Immunology Cancer and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Nathaniel TalledgePharmaconeuroimmunology Training Program, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.
Louis M ManskyDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA; Division of Basic Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA; Pharmaconeuroimmunology Training Program, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.
Joseph SodroskiDepartment of Immunology Cancer and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02215, USA.
Alon HerschhornDivision of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: aherschh@umn.edu.
University of Minnesota · USDana-Farber Cancer Institute · US

Funding

Training in PharmacoNeuroImmune Substance Abuse ResearchT32DA007097 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MOLITOR, THOMAS WILLIAM · 1985 to 2021
$13.1M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Understanding Envelope Function in HIV-1 Infection: The Design, Synthesis and Validation of Small Molecule HIV-1 Env InhibitorsP01AI150471 · NIAID · DREXEL UNIVERSITY · PI ABRAMS, CAMERON F · 2019 to 2022
$7.8M
DELINEATION AND VULNERABILITIES OF HIV-1 ESCAPE FROM NEUTRALIZING ANTIBODIESDP2DA049279 · NIDA · UNIVERSITY OF MINNESOTA · PI HERSCHHORN, ALON · 2019 to 2019
$2.3M
HIV Gag lattice morphology and particle biogenesisR01AI150468 · NIAID · UNIVERSITY OF MINNESOTA · PI MANSKY, LOUIS M., MUELLER, JOACHIM D · 2019 to 2020
$1.2M
Molecular Determinants of Retroviral Capsid Morphology using a Novel Imaging ApproachF32AI150351 · NIAID · UNIVERSITY OF MINNESOTA · PI TALLEDGE, NATHANIEL LEE · 2020 to 2021
$141k
NIAID NIH HHS F32 AI150351NIAID NIH HHS P01 AI150471NIAID NIH HHS R01 AI150468NIDA NIH HHS DP2 DA049279NIDA NIH HHS T32 DA007097NIGMS NIH HHS P41 GM103311
6 · The paper itself

Abstract

Many HIV strains downregulate the levels of CD4 receptor on the surface of infected cells to prevent superinfection. In contrast, the rare HIV-2

Indexed as

HIV-2HumansProtein BindingProtein Conformationbinding kineticsHIV envelope glycoproteinslong-lived activation statemolecular mechanism of HIV entry

Identifiers

PMID32521274
PMCPMC7336836
OpenAlexW3033486503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.