Evidence map›Paper›PMID 32521230›Full record

ArticleCell chemical biology2020

A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome.

Mark Jelcic, Ke Wang, King Lam Hui, Xiao-Chuan Cai, Balázs Enyedi, Minkui Luo, Philipp Niethammer

Open access · bronzeAbstract read
In one paragraph

Article in Cell chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Chemoproteomics, A Broad Avenue to Target Deconvolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
  2. Article
  3. Functionalised Cofactor Mimics for Interactome Discovery and Beyond.Angewandte Chemie (International ed. in English) · 2022
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Chemical Proteomics Approach for Profiling the NAD Interactome.Journal of the American Chemical Society · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Mark JelcicCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Ke WangChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
King Lam HuiCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Xiao-Chuan CaiChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Balázs EnyediDepartment of Physiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary; MTA-SE Lendület Tissue Damage Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary; HCEMM-SE Inflammatory Signaling Research Group, Department of Physiology, Semmelweis University, Budapest, Hungary.
Minkui LuoChemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Philipp NiethammerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: niethamp@mskcc.org.
Memorial Sloan Kettering Cancer Center · USSemmelweis University · HU

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Interrogating Protein Methyltransferases with Integrated ApproachesR35GM131858 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Minkui Luo · 2019 to 2026
$6.3M
Regulation of Wound Detection in Animal TissuesR01GM099970 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI NIETHAMMER, PHILIPP MICHAEL · 2012 to 2020
$3.2M
NCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM099970NIGMS NIH HHS R35 GM131858
6 · The paper itself

Abstract

ATP is an important energy metabolite and allosteric signal in health and disease. ATP-interacting proteins, such as P2 receptors, control inflammation, cell death, migration, and wound healing. However, identification of allosteric ATP sites remains challenging, and our current inventory of ATP-controlled pathways is likely incomplete. Here, we develop and verify mipATP as a minimally invasive photoaffinity probe for ATP-interacting proteins. Its N

Indexed as

Adenosine TriphosphateAmino AcidsAnimalsAnimals, Genetically ModifiedCalcium SignalingCalmodulinCell Line, TumorCell MembraneChromatography, High Pressure LiquidClick ChemistryFluorescent DyesHumansIsotope LabelingLarvaOptical ImagingProteomeAdenosine TriphosphateAmino AcidsCalmodulinFluorescent DyesProteomeATPATP photoaffinity probecalcium signalingchemical proteomicsphotoaffinity labelingpurinergic signalingquantitative proteomicstarget discovery

Identifiers

PMID32521230
PMCPMC7552919
OpenAlexW3033754934

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.