Evidence map›Paper›PMID 32521209›Full record

ArticleRNA biology2020

The stress specific impact of ALKBH1 on tRNA cleavage and tiRNA generation.

Sherif Rashad, Xiaobo Han, Kanako Sato, Eikan Mishima, Takaaki Abe, Teiji Tominaga, Kuniyasu Niizuma

Open access · bronzeAbstract read
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Unlocking the role of tRNA-derived fragments in shaping breast cancer signaling.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Queuosine tRNA Modification: Connecting the Microbiome to the Translatome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  14. Article
  15. Review
  16. The role of m5C, m1A and m7G modifications in tumors of urinary system.Frontiers in cell and developmental biology · 2025
    Review
  17. Methylations in dilated cardiomyopathy and heart failure.Frontiers in cardiovascular medicine · 2025
    Review
  18. A primer on tRNAs, tRNA-mFrontiers in cell and developmental biology · 2025
    Review
  19. Review
  20. Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Sherif RashadDepartment of Neurosurgery, Tohoku University Graduate School of Medicine , Sendai, Japan.ORCID 0000-0002-4511-6360
Xiaobo HanDepartment of Neurosurgery, Tohoku University Graduate School of Medicine , Sendai, Japan.
Kanako SatoDepartment of Neurosurgery, Tohoku University Graduate School of Medicine , Sendai, Japan.
Eikan MishimaDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai, Japan.ORCID 0000-0002-3706-2745
Takaaki AbeDivision of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine , Sendai, Japan.
Teiji TominagaDepartment of Neurosurgery, Tohoku University Graduate School of Medicine , Sendai, Japan.
Kuniyasu NiizumaDepartment of Neurosurgery, Tohoku University Graduate School of Medicine , Sendai, Japan.ORCID 0000-0001-9282-6499
Tohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

tiRNAs are small non-coding RNAs produced when tRNA is cleaved under stress. tRNA methylation modifications has emerged in recent years as important regulators for tRNA structural stability and sensitivity to cleavage and tiRNA generation during stress, however, the specificity and higher regulation of such a process is not fully understood. Alkbh1 is a m

Indexed as

RNA CleavageAlkB Homolog 1, Histone H2a DioxygenaseAnimalsApoptosisCell Line, TumorDNA MethylationGene Knockdown TechniquesHumansMethylationOxidative StressRatsRNA Processing, Post-TranscriptionalRNA, TransferRNA, UntranslatedStress, PhysiologicalALKBH1 protein, humanAlkB Homolog 1, Histone H2a DioxygenaseRNA, TransferRNA, UntranslatedAlkbh1apoptosiscell stressdemethylationoxidative stresstiRNAtRNA cleavage

Identifiers

PMID32521209
PMCPMC7549645
OpenAlexW3033342031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.