Evidence map›Paper›PMID 32520987›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2021

Altered Immune Reconstitution in Allogeneic Stem Cell Transplant Recipients With Human Immunodeficiency Virus (HIV).

Daniel D Murray, John Zaunders, Samuel T Milliken, C Mee Ling Munier, Carole Ford, C Orla Morrissey, Malini Visweswaran, Sharon Avery, Joseph Sasadeusz, John Kwan and 7 more

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In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 1 country.

Daniel D MurrayThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
John ZaundersThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
Samuel T MillikenDepartment of Haematology, St Vincent's Hospital Sydney, New South Wales, Australia.
C Mee Ling MunierThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
Carole FordSt Vincent's Centre for Applied Medical Research, Sydney, New South Wales, Australia.
C Orla MorrisseyDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
Malini VisweswaranSt Vincent's Centre for Applied Medical Research, Sydney, New South Wales, Australia.
Sharon AveryDepartment of Haematology, Alfred Health, Melbourne, Victoria, Australia.
Joseph SasadeuszDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
John KwanDepartment of Haematology, Westmead Hospital, Sydney, New South Wales, Australia.
Shrinivas DesaiDepartment of Haematology, St Vincent's Hospital Sydney, New South Wales, Australia.
Matthew LawThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
Kersten K KoelschThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
Sharon R LewinDepartment of Infectious Diseases, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
John MooreSt Vincent's Centre for Applied Medical Research, Sydney, New South Wales, Australia.
Anthony D KelleherThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
Mark N PolizzottoThe Kirby Institute for Infection and Immunity in Society, UNSW Sydney, Sydney, New South Wales, Australia.
UNSW Sydney · AUMonash University · AUSt Vincent's Hospital Sydney · AUSt Vincents Institute of Medical Research · AUAlfred Health · AUWestmead Hospital · AU

Funding

Viral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHACKER, TIMOTHY W · 2011 to 2015
$29.5M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
NIAID NIH HHS U19 AI096109NIAID NIH HHS UM1 AI126611
6 · The paper itself

Abstract

backgroundPersons living with human immunodeficiency virus (HIV) are at elevated risk of developing the malignant diseases that require allogeneic stem cell transplantation (ASCT). Recent data suggest that these individuals are also at an elevated risk of certain complications post-ASCT. This risk may result from preexisting HIV-related factors affecting dynamics of immune reconstitution post-ASCT. However, to date, there has been little work describing the dynamics of immune reconstitution post-ASCT in persons with HIV and none comparing these data to controls without HIV.

methodsWe assessed T-cell reconstitution in 6 ASCT with HIV recipients (HIV+ASCT) compared to a control population of 21 ASCT without HIV recipients. In a subset of HIV+ASCT recipients we performed additional flow cytometry profiling of CD8+ T-cell subsets and antigen specificity of reconstituting CD4+ and CD8+ T cells.

resultsWe observe no difference in post-ASCT CD4+ T cells between HIV+ASCT and HIV-negative ASCT recipients, despite much lower pre-ASCT CD4+ T-cell counts in the HIV+ASCT group. In contrast, we observed significantly higher CD8+ T-cell numbers in the HIV+ASCT group post-ASCT. The reconstituting CD8+ T-cells were predominantly CD45RO+, whereas homing markers and antigen specificity of these cells varied between participants.

conclusionThis study represents the most extensive characterization of immune-reconstitution post-ASCT in persons with HIV, and the first to our knowledge to compare these data to ASCT controls without HIV. The results indicate that immune reconstitution in this group can be affected by preexisting HIV infection and post-ASCT antigen exposure.

Indexed as

Hematopoietic Stem Cell TransplantationHIV InfectionsImmune ReconstitutionCD8-Positive T-LymphocytesHIVHumansacute leukemiaallogeneic stem cell transplantHIVimmune reconstitutionlymphoma

Identifiers

PMID32520987
PMCPMC8028103
OpenAlexW3033810913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.