ArticleGenetics and molecular biology2020
ACE2 diversity in placental mammals reveals the evolutionary strategy of SARS-CoV-2.
Article in Genetics and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
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- Structural Profiles of SARS-CoV-2 Variants in India.Current microbiology · 2022Article
- Natural infection of Delta mutant of SARS-CoV-2 in Asiatic lions of India.Transboundary and emerging diseases · 2022Article
- Lineage-specific positive selection onNational science review · 2022Article
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- Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID-19 and response to treatment.Pharmacology research & perspectives · 2022Review
- Investigating SARS-CoV-2 Susceptibility in Animal Species: A Scoping Review.Environmental health insights · 2022Article
- Evolutionary history of the SARS-CoV-2 Gamma variant of concern (P.1): a perfect storm.Genetics and molecular biology · 2022Article
- E484K as an innovative phylogenetic event for viral evolution: Genomic analysis of the E484K spike mutation in SARS-CoV-2 lineages from Brazil.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Dynamics of host immune responses to SARS-CoV-2.World journal of clinical cases · 2021Review
- Genetic and epigenetic factors associated with increased severity of Covid-19.Cell biology international · 2021Review
- Control and prevention of infectious diseases from a One Health perspective.Genetics and molecular biology · 2021Article
- Zoonotic spillover: Understanding basic aspects for better prevention.Genetics and molecular biology · 2021Article
- Predicting susceptibility for SARS-CoV-2 infection in domestic and wildlife animals using ACE2 protein sequence homology.Zoo biology · 2021Article
- COVID-19: The question of genetic diversity and therapeutic intervention approaches.Genetics and molecular biology · 2021Article
- Evolution, Ecology, and Zoonotic Transmission of Betacoronaviruses: A Review.Frontiers in veterinary science · 2021Review
- COVID-19 susceptibility: potential ofThe Egyptian journal of medical human genetics · 2020Review
- Assessing the SARS-CoV-2 threat to wildlife: Potential risk to a broad range of mammals.Perspectives in ecology and conservationReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent emergence of SARS-CoV-2 is responsible for the current pandemic of COVID-19, which uses the human membrane protein ACE2 as a gateway to host-cell infection. We performed a comparative genomic analysis of 70 ACE2 placental mammal orthologues to identify variations and contribute to the understanding of evolutionary dynamics behind this successful adaptation to infect humans. Our results reveal that 4% of the ACE2 sites are under positive selection, all located in the catalytic domain, suggesting possibly taxon-specific adaptations related to the ACE2 function, such as cardiovascular physiology. Considering all variable sites, we selected 30 of them located at the critical ACE2 binding sites to the SARS-CoV-like viruses for analysis in more detail. Our results reveal a relatively high diversity of ACE2 between placental mammal species, while showing no polymorphism within human populations, at least considering the 30 inter-species variable sites. A perfect scenario for natural selection favored this opportunistic new coronavirus in its trajectory of infecting humans. We suggest that SARS-CoV-2 became a specialist coronavirus for human hosts. Differences in the rate of infection and mortality could be related to the innate immune responses, other unknown genetic factors, as well as non-biological factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.