Evidence map›Paper›PMID 32520907›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

Outcomes After Being Lost to Follow-up Differ for Pregnant and Postpartum Women When Compared With the General HIV Treatment Population in Rural South Africa.

David Etoori, Francesc Xavier Gomez-Olive, Georges Reniers, Brian Rice, Jenny Renju, Chodziwadziwa W Kabudula, Alison Wringe

Abstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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  5. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David EtooriDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Francesc Xavier Gomez-OliveMRC/WITS Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Georges ReniersDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Brian RiceDepartment of Public Health Environments and Society, MeSH Consortium, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom; and.
Jenny RenjuDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Chodziwadziwa W KabudulaMRC/WITS Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Alison WringeDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Funding

Medical Research Council MR/P014313/1
6 · The paper itself

Abstract

backgroundUndetermined attrition prohibits full understanding of the coverage and effectiveness of HIV programs. Outcomes following loss to follow-up (LTFU) among antiretroviral therapy (ART) patients may differ according to their reasons for ART initiation.

settingWe compare the true outcomes of adult patients previously identified as LTFU by reason for ART initiation in 8 health facilities in north eastern South Africa.

methodsAdult HIV patient records were linked to health and demographic surveillance system (HDSS) data from 2014 to 2017. Outcomes of adults categorized as LTFU (>90 days late for the last scheduled clinic visit) were determined through clinic and routine tracing record reviews, consultation of HDSS data, and supplementary tracing. We calculated the proportion of patients per outcome category and performed competing risk survival analysis to estimate the cumulative incidence of death, transfer, migration, ART interruption, and re-engagement following LTFU.

resultsOf 895/1017 patients LTFU with an outcome ascertained, 120 (13.4%) had died, 225 (25.1%) re-engaged, 50 (5.6%) migrated out of the HDSS, 75 (8.4%) were alive and not on treatment, and 315 (35.1%) transferred their treatment. These outcomes varied by sex and pregnancy status at ART initiation. Mortality was less likely among pregnant women, patients with higher baseline CD4, and more likely among older patients.

conclusionsPatient survival and transfers to other facilities are considerably higher than those suggested in earlier studies. Outcomes differ for women who were pregnant or postpartum when initiating ART, with this population less likely to have died and more likely to have migrated.

Indexed as

AdultAnti-HIV AgentsFemaleHIV InfectionsHumansLost to Follow-UpPostpartum PeriodPregnancyPregnancy Complications, InfectiousProgram EvaluationRisk FactorsRural PopulationSouth AfricaSurvival AnalysisTreatment OutcomeAnti-HIV Agents

Identifiers

PMID32520907
PMCPMC7495979

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.