ReviewAdvances in anatomic pathology2020
Renal Hypoplasia, From Grossly Insufficient to Not Quite Enough: Consideration for Expanded Concepts Based Upon the Author's Perspective With Historical Review.
Review in Advances in anatomic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 29 citations in OpenAlex.
- Development of a fetal renal ultrasound score for predicting neonatal renal dysfunction.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Ask-Upmark Kidney Disease: Case Report of a Rare Congenital Malformation.Case reports in pathology · 2026Article
- Renal Hypoplasia and Oligomeganephronia in a Fetus with Wolf-Hirschhorn Syndrome.Diagnostics (Basel, Switzerland) · 2025Article
- Neonatal Renal Ultrasound Reference Values in Romanian Term Newborns: Correlations with Anthropometric Characteristics.Children (Basel, Switzerland) · 2025Article
- Severe Hypokalemic Paralysis Unmasking Renal Tubular Acidosis in a Patient With Sjögren's Syndrome.Cureus · 2025Article
- Pathophysiology of Congenital Anomalies of the Kidney and Urinary Tract: A Comprehensive Review.Cells · 2024Review
- Immunoexpression Pattern of Autophagy-Related Proteins in Human Congenital Anomalies of the Kidney and Urinary Tract.International journal of molecular sciences · 2024Article
- Spectrum of congenital anomalies of the kidney and urinary tract (CAKUT) including renal parenchymal malformations during fetal life and the implementation of prenatal exome sequencing (WES).Archives of gynecology and obstetrics · 2024Article
- Oligomeganephronia with PAX2 gene deletion diagnosed at the third renal biopsy: a case report.Journal of nephrology · 2024Article
- A case of pediatric secondary hypertension caused by juxtaglomerular cell tumor.Quantitative imaging in medicine and surgery · 2023Article
- Review
- Pathological and clinical characteristics of late-onset oligomeganephronia based on a histomorphometric study.BMC nephrology · 2023Article
- Article
- Renal insufficiency in children born preterm: examining the role of neonatal acute kidney injury.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- A Homozygous Dab1Biomolecules · 2021Article
- Article
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1 author at 1 institution in 1 country.
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Abstract
Hypoplasia is defined in the Merriman-Webster dictionary as "a condition of arrested development in which an organ, or part, remains below the normal size, or in an immature state." The degree of reduced size is not definitional. Renal hypoplasia, however, has historically been defined as a more marked reduction in renal mass such that presentation in childhood is the norm. There are 3 commonly recognized types of renal hypoplasia, simple hypoplasia, oligomeganephronic hypoplasia (oligomeganephronia) and segmental hypoplasia (Ask-Upmark kidney). They have in common a reduction in the number of renal lobes. A fourth type, not widely recognized, is cortical hypoplasia where nephrogenesis is normal but there is a reduction in the number of nephron generations. Recently there has been great interest in milder degrees of reduced nephron mass, known as oligonephronia because of its association with risk of adult-onset hypertension and chronic kidney disease. Since the last pathology review of this topic was published by Jay Bernstein in 1968, an update of the renal pathology findings in renal hypoplasia is provided with a review of 18 new cases. The renal hypoplasias are then framed within the modern concept of oligonephronia, its diverse causes and prognostic implications.
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