ArticleMolecular biology of the cell2020
Epithelial tissue geometry directs emergence of bioelectric field and pattern of proliferation.
Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Bioelectric fields drive pulmonary epithelial proliferation through PI3K/AKT/GSK3β signaling.Molecular and cellular biochemistry · 2026Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- Article
- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- CaCellular signalling · 2023Review
- Multicellular aligned bands disrupt global collective cell behavior.Acta biomaterialia · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis.Science advances · 2023Article
- Optical Control of Tissue Regeneration through Photostimulation of Organic Semiconducting Nanoparticles.Advanced healthcare materials · 2022Article
- A computational model of organism development and carcinogenesis resulting from cells' bioelectric properties and communication.Scientific reports · 2022Article
- Impact of Membrane Voltage on Formation and Stability of Human Renal Proximal TubulesACS biomaterials science & engineering · 2022Article
- Bioelectricity: From Endogenous Mechanisms to Opportunities in Synthetic Bioengineering.Bioelectricity · 2022Article
- Self-Sustained Regulation or Self-Perpetuating Dysregulation: ROS-dependent HIF-YAP-Notch Signaling as a Double-Edged Sword on Stem Cell Physiology and Tumorigenesis.Frontiers in cell and developmental biology · 2022Review
- Substratum stiffness tunes membrane voltage in mammary epithelial cells.Journal of cell science · 2021Article
- Global feather orientations changed by electric current.iScience · 2021Article
- Microtissue Geometry and Cell-Generated Forces Drive Patterning of Liver Progenitor Cell Differentiation in 3D.Advanced healthcare materials · 2021Article
- Bioengineering in vitro models of embryonic development.Stem cell reports · 2021Review
- A Note of Caution: Gramicidin Affects Signaling Pathways Independently of Its Effects on Plasma Membrane Conductance.BioMed research international · 2021Article
- Calcium, an Emerging Intracellular Messenger for the Hippo Pathway Regulation.Frontiers in cell and developmental biology · 2021Review
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5 authors.
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Abstract
Patterns of proliferation are templated by both gradients of mechanical stress as well as by gradients in membrane voltage (Vm), which is defined as the electric potential difference between the cytoplasm and the extracellular medium. Either gradient could regulate the emergence of the other, or they could arise independently and synergistically affect proliferation within a tissue. Here, we examined the relationship between endogenous patterns of mechanical stress and the generation of bioelectric gradients in mammary epithelial tissues. We observed that the mechanical stress gradients in the tissues presaged gradients in both proliferation and depolarization, consistent with previous reports correlating depolarization with proliferation. Furthermore, disrupting the Vm gradient blocked the emergence of patterned proliferation. We found that the bioelectric gradient formed downstream of mechanical stresses within the tissues and depended on connexin-43 (Cx43) hemichannels, which opened preferentially in cells located in regions of high mechanical stress. Activation of Cx43 hemichannels was necessary for nuclear localization of Yap/Taz and induction of proliferation. Together, these results suggest that mechanotransduction triggers the formation of bioelectric gradients across a tissue, which are further translated into transcriptional changes that template patterns of growth.
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