Evidence map›Paper›PMID 32520619›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.

Vienna E Brunt, Rachel A Gioscia-Ryan, Abigail G Casso, Nicholas S VanDongen, Brian P Ziemba, Zachary J Sapinsley, James J Richey, Melanie C Zigler, Andrew P Neilson, Kevin P Davy and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05296395 (Impact of Lp299v on Vascular Aging in Healthy Adults), which is not on this map. Cited by 175 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 7 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05296395 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Impact of Lp299v on Vascular Aging in Healthy Adults

TypeinterventionalSponsorMedical College of WisconsinRan2023 to 2027Enrolled20ConditionsVascular AgingArmsLactobacillus Plantarum 299v in fermented oat drink, Heat-Killed Placebo control fermented drink
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 7 syntheses or guidelines pooled it, 255 citations in OpenAlex.

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  13. [Correlation between trimethylamine-N-oxide and cardiovascular metabolic markers].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
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115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Vienna E BruntFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Rachel A Gioscia-RyanFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Abigail G CassoFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Nicholas S VanDongenFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Brian P ZiembaFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Zachary J SapinsleyFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
James J RicheyFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Melanie C ZiglerFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
Andrew P NeilsonDepartment of Food Science and Technology (A.P.N.), Virginia Tech, Blacksburg.
Kevin P DavyDepartment of Human Nutrition, Foods, and Exercise (K.P.D.), Virginia Tech, Blacksburg.
Douglas R SealsFrom the Department of Integrative Physiology, University of Colorado Boulder (V.E.B., R.A.G.-R., A.G.C., N.S.V., B.P.Z., Z.J.S., J.J.R., M.C.Z., D.R.S.).
University of Colorado Boulder · US

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Translational Studies of Age-Associated Arterial Dysfunction, Western Diet and Aerobic Exercise: Role of the Gut MicrobiomeR01HL134887 · NHLBI · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2017 to 2020
$3.1M
DMB (3,3-dimethyl-1-butanol) as a novel translational strategy for preventing and treating gut dysbiosis-associated arterial agingR21AG060884 · NIA · UNIVERSITY OF COLORADO · PI SEALS, DOUGLAS R · 2019 to 2020
$437k
Translational studies of gut-derived trimethylamine N-oxide: a target for prevention and treatment of age-associated vascular endothelial dysfunctionF32HL140875 · NHLBI · UNIVERSITY OF COLORADO · PI BRUNT, VIENNA E · 2018 to 2019
$89k
NCATS NIH HHS UL1 TR002535NHLBI NIH HHS F32 HL140875NHLBI NIH HHS R01 HL134887NIA NIH HHS R21 AG060884
6 · The paper itself

Abstract

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with aging. In healthy humans, plasma trimethylamine-N-oxide was higher in middle-aged/older (64±7 years) versus young (22±2 years) adults (6.5±0.7 versus 1.6±0.2 µmol/L) and inversely related to brachial artery flow-mediated dilation (

Indexed as

AcetylcholineAdolescentAdultAgedAgingAnimalsAntioxidantsAscorbic AcidBrachial ArteryCarotid ArteriesCyclic N-OxidesDietary SupplementsEndothelium, VascularGastrointestinal MicrobiomeHumansMethylamines3-nitrotyrosineAcetylcholineAntioxidantsAscorbic AcidCyclic N-OxidesMethylaminesNitric OxideNitric Oxide Synthase Type IIINos3 protein, mouseSpin LabelsSuperoxidestempoltrimethyloxamineTyrosineacetylcholineagingbrachial arterymicrobiota nitric oxidesuperoxide

Identifiers

PMID32520619
PMCPMC7295014
OpenAlexW3033622977

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.