SynthesisHypertension (Dallas, Tex. : 1979)2020
Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure.
Open access · bronzeAbstract readMeta-Analysis
In one paragraph
Synthesis in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Regulation of nc886 (vtRNA2-1) RNAs is associated with cardiometabolic risk factors and diseases.Clinical epigenetics · 2025Pooled it
- Epigenome-wide association study of BMI in Black populations from InterGEN and GENOA.Obesity (Silver Spring, Md.) · 2023Pooled it
- Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.Nature communications · 2022Pooled it
- Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts.Diabetologia · 2022Pooled it
- Trial
- Hypertension-associated DNA methylation signatures and multi-generational epigenetic clocks in Korean adults.GeroScience · 2026Article
- Genetic Regulation of DNA Methylation and Its Mediating Role in Blood Pressure: A Genome-Wide Twin Study.MedComm · 2026Article
- Age-varying DNA methylation patterns associated with blood pressure in mid-to-late adulthood.Clinical epigenetics · 2026Article
- Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4.BMC medicine · 2026Article
- Associations Between 40-Year Trajectories of BMI and Proteomic and Epigenetic Aging Clocks: Deciphering Nonlinearity and Interactions.Aging cell · 2026Article
- DAB2IP: unifying cardiovascular pathogenesis and cardiovascular brain crosstalk.Frontiers in cardiovascular medicine · 2026Review
- Age-varying DNA methylation patterns associated with blood pressure across the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations.Epigenetics · 2025Article
- Impact of psychosocial stress in early life on pace of aging in young adulthood.Clinical epigenetics · 2025Article
- Longitudinal changes in the genetic and environmental influences on DNA methylation linked to obesity measures: a 5-year twin study.Molecular biomedicine · 2025Article
- An Integrative Polygenic and Epigenetic Risk Score for Overweight-related Hypertension in Chinese Population.Genomics, proteomics & bioinformatics · 2025Article
- Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study.Diabetes, obesity & metabolism · 2025Article
- Multi-Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences.Aging cell · 2025Article
- Genetic influences on the association between DNA methylation and obesity measures: insights from a twin study design.Cell & bioscience · 2025Article
- Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability.Journal of proteome research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
52 authors at 17 institutions in 7 countries.
Yisong Huang *From the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
Miina Ollikainen *Institute for Molecular Medicine FIMM, HiLIFE (M.O., M.M., K.H., J.K.), University of Helsinki, Finland.
Maheswary Muniandy *Institute for Molecular Medicine FIMM, HiLIFE (M.O., M.M., K.H., J.K.), University of Helsinki, Finland.
Tao ZhangDepartment of Biostatistics, Shandong University School of Public Health, Jinan, China (T.Z.).
Jenny van DongenDepartment of Biological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands (J.v.D., G.W., D.I.B., E.J.C.d.G.).
Guang HaoFrom the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
Peter J van der MostDepartment of Epidemiology (P.J.v.d.M., E.F., X.L., J.V.v.V.-O., H.S.), University Medical Center Groningen, University of Groningen, The Netherlands.
Yue PanFrom the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
Natalia PervjakovaEstonian Genome Center, Institute of Genomics, University of Tartu, Estonia (N.P., L.M.).
Yan V SunDepartment of Epidemiology, Emory Rollins School of Public Health, Emory University, Atlanta (Y.V.S., Q.H., Y. Huang, V.V.).
Qin HuiDepartment of Epidemiology, Emory Rollins School of Public Health, Emory University, Atlanta (Y.V.S., Q.H., Y. Huang, V.V.).
Jari LahtiTurku Institute for Advanced Studies (J.L.), University of Turku, Finland.
Eliza FraszczykDepartment of Epidemiology (P.J.v.d.M., E.F., X.L., J.V.v.V.-O., H.S.), University Medical Center Groningen, University of Groningen, The Netherlands.
Xueling LuDepartment of Epidemiology (P.J.v.d.M., E.F., X.L., J.V.v.V.-O., H.S.), University Medical Center Groningen, University of Groningen, The Netherlands.
Dianjianyi SunDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (D.S., W.C.).
Melissa A RichardDepartment of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine (M.A.R.).
Gonneke WillemsenDepartment of Biological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands (J.v.D., G.W., D.I.B., E.J.C.d.G.).
Kauko HeikkilaInstitute for Molecular Medicine FIMM, HiLIFE (M.O., M.M., K.H., J.K.), University of Helsinki, Finland.
Irene Mateo LeachDepartment of Cardiology (I.M.L., P.v.d.H.), University Medical Center Groningen, University of Groningen, The Netherlands.
Nina MononenDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere (N.M., T.L.), Faculty of Medicine and Health Technology, Tampere University, Finland.
Mika KähönenDepartment of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology (M.K.), Faculty of Medicine and Health Technology, Tampere University, Finland.
Mikko A HurmeDepartment of Microbiology and Immunology (M.A.H.), Faculty of Medicine and Health Technology, Tampere University, Finland.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine (O.T.R.), University of Turku, Finland.
Amanda J DrakeUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, United Kingdom (A.J.D., B.K.).
Markus PerolaNational Institute for Health and Welfare, Helsinki, Finland (M.P., M.-L.N., V.S.).
Marja-Liisa NuotioNational Institute for Health and Welfare, Helsinki, Finland (M.P., M.-L.N., V.S.).
Yunfeng HuangDepartment of Epidemiology, Emory Rollins School of Public Health, Emory University, Atlanta (Y.V.S., Q.H., Y. Huang, V.V.).
Batbayar KhulanUniversity/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, United Kingdom (A.J.D., B.K.).
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Finland (J.L., K.R.).
Bruce H R WolffenbuttelDepartment of Endocrinology (B.H.R.W., J.V.v.V.-O.), University Medical Center Groningen, University of Groningen, The Netherlands.
Alexandra ZhernakovaDepartment of Genetics (A.Z., J.F., L.F.), University Medical Center Groningen, University of Groningen, The Netherlands.
Jingyuan FuDepartment of Genetics (A.Z., J.F., L.F.), University Medical Center Groningen, University of Groningen, The Netherlands.
Haidong ZhuFrom the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
Yanbin DongFrom the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
Jana V van Vliet-OstaptchoukDepartment of Epidemiology (P.J.v.d.M., E.F., X.L., J.V.v.V.-O., H.S.), University Medical Center Groningen, University of Groningen, The Netherlands.
Lude FrankeDepartment of Genetics (A.Z., J.F., L.F.), University Medical Center Groningen, University of Groningen, The Netherlands.
Johan G ErikssonDepartment of General Practice and Primary health Care, University of Helsinki, Finland and Helsinki University Hospital, Unit of General Practice, Finland (J.G.E.).
Myriam FornageBrown Foundation Institute of Molecular Medicine, Mc Govern Medical School, University of Texas Health Science Center at Houston (M.F.).
Lili MilaniEstonian Genome Center, Institute of Genomics, University of Tartu, Estonia (N.P., L.M.).
Terho LehtimäkiDepartment of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere (N.M., T.L.), Faculty of Medicine and Health Technology, Tampere University, Finland.
Viola VaccarinoDepartment of Epidemiology, Emory Rollins School of Public Health, Emory University, Atlanta (Y.V.S., Q.H., Y. Huang, V.V.).
Dorret I BoomsmaDepartment of Biological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands (J.v.D., G.W., D.I.B., E.J.C.d.G.).
Pim van der HarstDepartment of Cardiology (I.M.L., P.v.d.H.), University Medical Center Groningen, University of Groningen, The Netherlands.
Eco J C de GeusDepartment of Biological Psychology, Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, The Netherlands (J.v.D., G.W., D.I.B., E.J.C.d.G.).
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland (M.P., M.-L.N., V.S.).
Shengxu LiDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (J.W.).
Wei ChenDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (D.S., W.C.).
Shaoyong Su *From the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
James Wilson *
Harold Snieder *Department of Epidemiology (P.J.v.d.M., E.F., X.L., J.V.v.V.-O., H.S.), University Medical Center Groningen, University of Groningen, The Netherlands.
Jaakko Kaprio *Institute for Molecular Medicine FIMM, HiLIFE (M.O., M.M., K.H., J.K.), University of Helsinki, Finland.
Xiaoling Wang *From the Georgia Prevention Institute, Medical College of Georgia, Augusta University (Y. Huang, G.H., Y.P., H.Z., Y.D., S.S., X.W.).
University Medical Center Groningen · NLUniversity of Helsinki · FIAugusta University · USEmory University · USVrije Universiteit Amsterdam · NLFinnish Institute for Health and Welfare · FITampere University · FIBritish Heart Foundation · GBEstonian Biocentre · EETulane University · USBaylor College of Medicine · USBrown Foundation · USShandong University · CNTampere University of Applied Sciences · FIUniversity of Mississippi Medical Center · USUniversity of Turku · FIWilson Community College · US
Funding
NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8MTracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GOMEZ-SANCHEZ, CELSO ENRIQUE · 2016 to 2025
$38.2MVascular and renal responses to stressP01HL069999 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI GEORGE, VARGHESE · 2002 to 2018
$31.1MTulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Katherine Teresa Mills · 2016 to 2026
$25.3MEVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MIntegration of Genomics & Transcriptomics in Normal Twins & Major DepressionRC2MH089951 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2009 to 2010
$6.5MCannabinoid Receptors and Associated Proteins-RenewalR01DA042157 · NIDA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLYN C HOWLETT, W TODD LOWTHER · 2017 to 2026
$5.4MMechanisms Linking Depression to Cardiovascular RiskR01HL068630 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2001 to 2010
$4.8MPsychometric and Genetic Assessments of Substance UseR37DA018673 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEALE, MICHAEL CHURTON · 2005 to 2014
$3.7MPTSD and Ischemic Heart Disease Progression: A Longitudinal Twin StudyR01HL125246 · NHLBI · EMORY UNIVERSITY · PI VACCARINO, VIOLA · 2015 to 2018
$3.4MEpigenetic Basis of Obesity Induced Cardiovascular Disease and Type 2 DiabetesR01HL105689 · NHLBI · AUGUSTA UNIVERSITY · PI WANG, XIAOLING · 2011 to 2015
$3.3MEPA EP-C-15-001NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS K24 HL077506NHLBI NIH HHS P01 HL069999NHLBI NIH HHS R01 HL064157NHLBI NIH HHS R01 HL068630NHLBI NIH HHS R01 HL104125NHLBI NIH HHS R01 HL105689NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL125246NHLBI NIH HHS R01 HL125577NHLBI NIH HHS R01 HL136205NHLBI NIH HHS R21 HL106333NIA NIH HHS R01 AG016592NIA NIH HHS R01 AG026255NIA NIH HHS R03 AG060619NIDA NIH HHS R01 DA018673NIDA NIH HHS R01 DA042157NIDA NIH HHS R37 DA018673NIDDK NIH HHS R01 DK092127NIGMS NIH HHS P20 GM109036NIGMS NIH HHS U54 GM115428NIMHD NIH HHS HHSN268201800013INIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089951NIMH NIH HHS U24 MH068457
Abstract
We conducted an epigenome-wide association study meta-analysis on blood pressure (BP) in 4820 individuals of European and African ancestry aged 14 to 69. Genome-wide DNA methylation data from peripheral leukocytes were obtained using the Infinium Human Methylation 450k BeadChip. The epigenome-wide association study meta-analysis identified 39 BP-related CpG sites with
Indexed as
DNA MethylationGene-Environment InteractionGenome-Wide Association StudyAdolescentAdultAgedBlack PeopleBlood PressureBody Mass IndexCohort StudiesCpG IslandsDiseases in TwinsEpigenomeEssential HypertensionFemaleGene Expressionblood pressureDNA methylationepigenomehypertensionTwin study
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.