Evidence map›Paper›PMID 32520431›Full record

ArticleBritish journal of clinical pharmacology2021

The pharmacotherapy team: A novel strategy to improve appropriate in-hospital prescribing using a participatory intervention action method.

Rashudy F Mahomedradja, Kim C E Sigaloff, Jessica K Bekema, Marieke J H J Dekker, David J Brinkman, Marianne A Kuijvenhoven, Marlou L H van Beneden, Birgit I Lissenberg-Witte, Jelle Tichelaar, Michiel A van Agtmael

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Article in British journal of clinical pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rashudy F MahomedradjaDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.ORCID 0000-0002-8495-6231
Kim C E SigaloffDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Jessica K BekemaDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Marieke J H J DekkerDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
David J BrinkmanDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Marianne A KuijvenhovenDepartment of Clinical Pharmacology and Pharmacy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Marlou L H van BenedenDepartment of Internal Medicine, Section of Acute Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Birgit I Lissenberg-WitteDepartment of Epidemiology and Biostatistics, Amsterdam UMC location VUmc, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Jelle TichelaarDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Michiel A van AgtmaelDepartment of Internal Medicine, Section Pharmacotherapy, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Amsterdam Neuroscience · NLAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsPrescribing medication is a complex process that, when done inappropriately, can lead to adverse drug events, resulting in patient harm and hospital admissions. Worldwide cost is estimated at 42 billion USD each year. Despite several efforts in the past years, medication-related harm has not declined. The aim was to determine whether a prescriber-focussed participatory action intervention, initiated by a multidisciplinary pharmacotherapy team, is able to reduce the number of in-hospital prescriptions containing ≥1 prescribing error (PE), by identifying and reducing challenges in appropriate prescribing.

methodsA prospective single-centre before- and after study was conducted in an academic hospital in the Netherlands. Twelve clinical wards (medical, surgical, mixed and paediatric) were recruited.

resultsOverall, 321 patients with a total of 2978 prescriptions at baseline were compared with 201 patients with 2438 prescriptions postintervention. Of these, m456 prescriptions contained ≥1 PE (15.3%) at baseline and 357 prescriptions contained ≥1 PEs (14.6%) postintervention. PEs were determined in multidisciplinary consensus. On some study wards, a trend toward a decreasing number of PEs was observed. The intervention was associated with a nonsignificant difference in PEs (incidence rate ratio 0.96, 95% confidence interval 0.83-1.10), which was unaltered after correction. The most important identified challenges were insufficient knowledge beyond own expertise, unawareness of guidelines and a heavy workload.

conclusionThe tailored interventions developed with and implemented by stakeholders led to a statistically nonsignificant reduction in inappropriate in-hospital prescribing after a 6-month intervention period. Our prescriber-focussed participatory action intervention identified challenges in appropriate in-hospital prescribing on prescriber- and organizational level.

Indexed as

Drug-Related Side Effects and Adverse ReactionsInappropriate PrescribingChildDrug PrescriptionsHospitalsHumansNetherlandsProspective Studiesclinical pharmacologymedical educationmedication errorsmedication safetyprescribing

Identifiers

PMID32520431
PMCPMC9328271
OpenAlexW3033364408

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.