ArticleHippocampus2020
Data-driven integration of hippocampal CA1 synaptic physiology in silico.
Article in Hippocampus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- eFEL: electrophysiology feature extraction library.Bioinformatics (Oxford, England) · 2026Article
- Visualization and simulation of full-scale point-neuron circuits via the Neural Circuit Visualizer web platform.Scientific reports · 2026Article
- Modeling and simulation of neocortical micro- and mesocircuitry (Part II, Physiology and experimentation).eLife · 2026Article
- Article
- Integrating multimodal data to understand cortical circuit architecture and function.Nature neuroscience · 2025Review
- Cell-type-specific contributions to theta-gamma coupled rhythms in the hippocampus.Network neuroscience (Cambridge, Mass.) · 2025Article
- Evaluation and comparison of methods for neuronal parameter optimization using the Neuroptimus software framework.PLoS computational biology · 2024Article
- Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices.Nature neuroscience · 2024Article
- Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region.PLoS biology · 2024Article
- Multi-scale spiking network model of human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Equal levels of pre- and postsynaptic potentiation produce unequal outcomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Morpho-electric diversity of human hippocampal CA1 pyramidal neurons.Cell reports · 2024Article
- Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.PLoS biology · 2024Article
- Cortical cell assemblies and their underlying connectivity: An in silico study.PLoS computational biology · 2024Article
- Article
- Hippocampome.org v2.0: a knowledge base enabling data-driven spiking neural network simulations of rodent hippocampal circuits.bioRxiv : the preprint server for biology · 2024Article
- A lightweight data-driven spiking neuronal network model ofFrontiers in neuroscience · 2024Article
- Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep.Cell reports · 2023Article
- Strong and reliable synaptic communication between pyramidal neurons in adult human cerebral cortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
The anatomy and physiology of monosynaptic connections in rodent hippocampal CA1 have been extensively studied in recent decades. Yet, the resulting knowledge remains disparate and difficult to reconcile. Here, we present a data-driven approach to integrate the current state-of-the-art knowledge on the synaptic anatomy and physiology of rodent hippocampal CA1, including axo-dendritic innervation patterns, number of synapses per connection, quantal conductances, neurotransmitter release probability, and short-term plasticity into a single coherent resource. First, we undertook an extensive literature review of paired recordings of hippocampal neurons and compiled experimental data on their synaptic anatomy and physiology. The data collected in this manner is sparse and inhomogeneous due to the diversity of experimental techniques used by different groups, which necessitates the need for an integrative framework to unify these data. To this end, we extended a previously developed workflow for the neocortex to constrain a unifying in silico reconstruction of the synaptic physiology of CA1 connections. Our work identifies gaps in the existing knowledge and provides a complementary resource toward a more complete quantification of synaptic anatomy and physiology in the rodent hippocampal CA1 region.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.