SynthesisRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
Childhood-maltreatment subtypes in bipolar patients with suicidal behavior: systematic review and meta-analysis.
Synthesis in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolic markers in bipolar disorder with childhood trauma exposure: a systematic review.CNS spectrums · 2026Pooled it
- Long-term stability of perceived childhood trauma in individuals with borderline personality disorder.European journal of psychotraumatology · 2026Article
- Sequelae of child maltreatment: Umbrella synthesis of 148 meta-analyses on the mental health correlates.JCPP advances · 2026Article
- Association Between Kynurenine Pathway and Cerebellar Microstructure in Bipolar Disorder With Childhood Trauma.Alpha psychiatry · 2026Article
- Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach.Translational psychiatry · 2026Article
- Childhood Maltreatment and Cognitive Performance in Bipolar Disorder: The Potential Role of Inflammation.Acta psychiatrica Scandinavica · 2026Article
- Staging of suicidality in bipolar disorder: Findings from the FACE-BD cohort (FondaMental Advanced Centers of Expertise for Bipolar Disorders).European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The effect of childhood trauma on bipolar depression.Scientific reports · 2025Article
- The Relationship Between Childhood Trauma and Physical and Mental Quality of Life in Patients with Severe Mental Disorders.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2025Article
- Network analysis of influential risk factors in adolescent suicide attempters.Child and adolescent psychiatry and mental health · 2024Article
- Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients.Molecular psychiatry · 2024Article
- Specific effects of five subtypes of childhood maltreatment on suicide behaviours in Chinese adolescents: the moderating effect of sex and residence.Epidemiology and psychiatric sciences · 2023Article
- Sex and sensitive period differences in potential effects of maltreatment on axial versus radial diffusivity in the corpus callosum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Influence of childhood maltreatment on prevalence, onset, and persistence of psychiatric comorbidities and suicide attempts in bipolar disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- The Association Between Suicide Attempts, Anxiety, and Childhood Maltreatment Among Adolescents and Young Adults With First Depressive Episodes.Frontiers in psychiatry · 2021Article
- The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress.Neuropsychiatric disease and treatment · 2020Review
- Negative early life experiences as risk factors for suicidal behavior in bipolar disorders.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePatients with bipolar disorders have a high risk of suicidal behavior. Childhood maltreatment is a well-established risk factor for suicidal behavior. The objective of this study was to examine the association between childhood-maltreatment subtypes and vulnerability to suicide attempts in bipolar disorder using the Childhood Trauma Questionnaire (CTQ).
methodsA literature review was performed using the MEDLINE, Embase, and PsycINFO databases. Thirteen studies met the selection criteria. In the meta-analysis, the Childhood Trauma Questionnaire (CTQ) was used to assess a wide range of childhood maltreatment subtypes, which were analyzed by using a random-effects model to account for the likely variations of true effect sizes between the included studies.
resultsIn the systematic review, 13 studies met the selection criteria. The CTQ was selected for the meta-analysis to increase the homogeneity of assessment and to encompass a wide range of childhood-maltreatment subtypes. The data were analyzed using a random-effects model. Compared to bipolar non-attempters, bipolar suicide attempters had experienced childhood maltreatment with a significantly higher frequency and had higher total CTQ scores (Hedges' g = -0.38, 95%CI -0.52 to -0.24, z = -5.27, p < 0.001) and CTQ sub-scores (sexual abuse: g = -0.39, 95%CI -0.52 to -0.26, z = -5.97; physical abuse: g = -0.26, 95%CI -0.39 to -0.13, z = -4.00; emotional abuse: g = -0.39, 95%CI -0.65 to -0.13, z = -2.97; physical neglect: g = -0.18, 95%CI -0.31 to -0.05, z = -2.79; emotional neglect: g = -0.27, 95%CI -0.43 to -0.11, z = -3.32).
conclusionsChildhood maltreatment, as assessed by the CTQ, may contribute to an increased risk of suicidal behavior among people with bipolar disorders. Recognizing maltreatment as an etiological risk factor is a crucial step toward furthering science-based preventive psychiatry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.