Evidence map›Paper›PMID 32520081›Full record

ArticleActa cirurgica brasileira2020

Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model.

Rogério José de Azevedo Meirelles, Fermino Sanches Lizarte Neto, Mucio Luiz de Assis Cirino, Paulo Cezar Novais, Isabella Stracieri Gula, Jairo Pinheiro da Silva, Maria de Fátima Galli Sorita Tazzima, Valéria Paula Sassoli Fazan, Marina Toledo Durand, Daniela Pretti da Cunha Tirapelli and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Rogério José de Azevedo MeirellesPhD, Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (FMRP-USP), Ribeirao Preto-SP, Brazil. Acquisition of data.ORCID http://orcid.org/0000-0001-9208-7120
Fermino Sanches Lizarte NetoPhD, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Technical procedures.ORCID http://orcid.org/0000-0002-0046-7300
Mucio Luiz de Assis CirinoFellow PhD degree, Postgraduate Program in Clinical Surgical, Department of Surgery and Anatomy, Surgical Clinic Program, FMRP-USP, Ribeirao Preto-SP, Brazil. Acquisition of data.ORCID http://orcid.org/0000-0001-7872-8331
Paulo Cezar NovaisPhD, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, and Postgarduate Program in Structural and Functional Interactions in Rehabiliattion, Universidade de Marília (UNIMAR), Marilia-SP, Brazil. Histopathological examinations.ORCID http://orcid.org/0000-0001-8372-6293
Isabella Stracieri GulaGraduate student, School of Medicine, Universidade de Ribeirão Preto (UNAERP), Brazil. Acquisition of data.ORCID http://orcid.org/0000-0003-0797-9525
Jairo Pinheiro da SilvaPhD, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, and Professor, Faculdade de Taquaritinga (FTGA), Brazil. Manuscript preparation.ORCID http://orcid.org/0000-0002-5213-8525
Maria de Fátima Galli Sorita TazzimaPhD, Assistant Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Manuscript writing.ORCID http://orcid.org/0000-0002-5844-7310
Valéria Paula Sassoli FazanPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Manuscript writing.ORCID http://orcid.org/0000-0003-1293-5308
Marina Toledo DurandPhD, UNAERP, Ribeirao Preto-SP, Brazil. Manuscript writing.ORCID http://orcid.org/0000-0002-5625-4662
Daniela Pretti da Cunha TirapelliPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Final approval.ORCID http://orcid.org/0000-0002-1886-4988
Camila Albuquerque Melo de CarvalhoPhD, Department of Surgery and Anatomy, FMRP-USP, and Professor, Centro Universitário Barão de Mauá, Ribeirao Preto-SP, Brazil. Manuscript writing.ORCID http://orcid.org/0000-0003-2325-2844
Bruno César SchimmingPhD, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, and Associate Professor, Department of Bioscience, Universidade Estadual Paulista (UNESP), Botucatu-SP, Brazil. Critical revision.ORCID http://orcid.org/0000-0002-0837-9612
Carlos Augusto Fernandes MolinaPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Final approval.ORCID http://orcid.org/0000-0002-5118-778X
Silvio Tucci JuniorPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Final approval.ORCID http://orcid.org/0000-0002-7656-0181
Luis Fernando TirapelliPhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Final approval.ORCID http://orcid.org/0000-0002-2251-1106
Universidade de Ribeirão Preto · BRCentro Universitário Barão de Mauá · BRFaculdade Brasil · BRUniversidade de Marília · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats.

methodsTwenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an adaptive phase, rats from group A received only ethanol solution (20%) during 7 weeks. The morphometric and caspase-3 immunohistochemistry analysis were performed in the corpus cavernosum. The miRNA-21 expression was analyzed in blood and cavernous tissue.

resultsChronic ethanol consumption decreased cavernosal smooth muscle area of alcoholic rats. The protein expression of caspase 3 in the corpus cavernosum was higher in A compared to the C group. There was no difference in the expression of miRNA-21 in serum and cavernous tissue between the groups.

conclusionChronic ethanol consumption reduced smooth muscle area and increased caspase 3 in the corpus cavernosum of rats, without altered serum and cavernosal miR-21 gene expression.

Indexed as

AlcoholismAnimalsApoptosisCaspase 3Disease Models, AnimalErectile DysfunctionGene ExpressionImmunohistochemistryMaleMicroRNAsMuscle, SmoothPenisRats, WistarReference ValuesCaspase 3MicroRNAsmirn21 microRNA, rat

Identifiers

PMID32520081
PMCPMC7282493
OpenAlexW3033348293

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.