ArticleChemical communications (Cambridge, England)2020
Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.
Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Diastereotopic Fluorines of CFChirality · 2026Article
- Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules.Magnetic resonance in chemistry : MRC · 2026Review
- Benchmark of Density Functional Theory in the Prediction ofJournal of chemical theory and computation · 2025Article
- Leptochelins A-C, Cytotoxic Metallophores Produced by Geographically DispersedJournal of the American Chemical Society · 2024Article
- Enzymatic Halogenation of Terminal Alkynes.Journal of the American Chemical Society · 2023Article
- The DP5 probability, quantification and visualisation of structural uncertainty in single molecules.Chemical science · 2022Article
- The Tetrahydrofuran Motif in Polyketide Marine Drugs.Marine drugs · 2022Review
- The Natural Products Atlas 2.0: a database of microbially-derived natural products.Nucleic acids research · 2022Article
- The Chemistry, Biochemistry and Pharmacology of Marine Natural Products fromMarine drugs · 2020Review
- Unequivocal structure confirmation of a breitfussin analog by anisotropic NMR measurements.Chemical science · 2020Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter.
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