Evidence map›Paper›PMID 32519904›Full record

ArticleLeukemia & lymphoma2020

Early evidence of pulmonary dysfunction in survivors of childhood Hodgkin lymphoma.

Jennifer E Agrusa, Viral D Kothari, Austin L Brown, Prakash M Masand, Gary D Lewis, Bin S Teh, Arnold C Paulino, Manuel D Silva-Carmona, Ernestina Melicoff, Carl E Allen and 1 more

Open access · greenAbstract read
In one paragraph

Article in Leukemia & lymphoma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jennifer E AgrusaDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-8932-863X
Viral D KothariDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-0046-0707
Austin L BrownDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0001-5802-5073
Prakash M MasandDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Gary D LewisDepartment of Radiation Oncology, University of Texas Medical Branch, Galveston, TX, USA.ORCID 0000-0003-2005-6522
Bin S TehDepartment of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA.ORCID 0000-0003-1456-9444
Arnold C PaulinoDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-0269-3045
Manuel D Silva-CarmonaDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-4908-8301
Ernestina MelicoffDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0001-5696-7112
Carl E AllenDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
Monica M GramatgesDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-0947-104X
Baylor College of Medicine · USMethodist Hospital · USThe University of Texas MD Anderson Cancer Center · US

Funding

PEDIATRIC ONCOLOGY CLINICAL RESEARCH TRAINING PROGRAMK12CA090433 · NCI · BAYLOR COLLEGE OF MEDICINE · PI CARL E ALLEN, Donald W. Parsons · 2002 to 2026
$18.5M
NCI NIH HHS K12 CA090433
6 · The paper itself

Abstract

Survivors of childhood Hodgkin lymphoma (HL) are at risk for pulmonary late effects, but whether survivors also experience pulmonary dysfunction early off therapy is not well understood. We determined the incidence of pulmonary dysfunction in children/adolescents with HL at entry into survivorship, as well as risk factors related to this outcome. Survivors in clinical remission and with a pulmonary function test (PFT) obtained 2-6 years off therapy were included. Seventy-five of 118 subjects met eligibility criteria (mean age at diagnosis: 13 years, mean time off therapy: 40 months). Survivors of HL had a higher than expected incidence of pulmonary dysfunction at entry into survivorship (40/75 [53%] had an abnormal DLCO and/or a restrictive or obstructive impairment). Evidence for diffusion impairment was associated with female sex (odds ratio [OR] = 3.19,

Indexed as

Hodgkin DiseaseAdolescentChildFemaleFollow-Up StudiesHumansIncidenceRisk FactorsSurvivorsChildhoodHodgkin lymphomapulmonary dysfunctionsurvivor

Identifiers

PMID32519904
PMCPMC8262456
OpenAlexW3033196101

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.