Evidence map›Paper›PMID 32519893›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

The ex vivo perfused human lung is resistant to injury by high-dose

James T Ross, Nicolas Nesseler, Aleksandra Leligdowicz, Rachel L Zemans, Rahul Y Mahida, Emily Minus, Chaz Langelier, Jeffrey E Gotts, Michael A Matthay

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Mechanisms of impaired alveolar fluid clearance.Anatomical record (Hoboken, N.J. : 2007) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. The future of sepsis research: time to think differently?American journal of physiology. Lung cellular and molecular physiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 4 countries.

James T RossDepartment of Surgery, University of California San Francisco, San Francisco, California.ORCID 0000-0002-8465-8250
Nicolas NesselerCardiovascular Research Institute, University of California San Francisco, San Francisco, California.
Aleksandra LeligdowiczCardiovascular Research Institute, University of California San Francisco, San Francisco, California.
Rachel L ZemansDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Rahul Y MahidaBirmingham Acute Care Research Group, Institute of Inflammation and Aging, University of Birmingham, Birmingham, United Kingdom.
Emily MinusAmherst College, Amherst, Massachusetts.
Chaz LangelierDivision of Infectious Diseases, Department of Medicine, University of California San Francisco, San Francisco, California.
Jeffrey E GottsDepartment of Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California.
Michael A MatthayDepartments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USAmherst College · USInserm · FRUniversity of Birmingham · GBUniversity of Michigan · US

Funding

Resolution of Clinical Lung InjuryR37HL051856 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2006 to 2015
$3.9M
NOVEL PARACRINE MECHANISMS FOR CELL-BASED THERAPY OF INJURED LUNGSR01HL134828 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI JI, HONG-LONG · 2017 to 2025
$3.4M
RESEARCH TRAINING IN GASTROINTESTINAL SURGERYT32DK007573 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARRIS, HOBART WHITAKER · 1988 to 2019
$3.0M
Albumin Nanoparticles Incorporating Piceatannol (PANPs) for ALI/ARDS therapyR42HL126456 · NHLBI · NANO BIOTHERAPEUTICS, INC. · PI KANTETI, PRASAD V. S., MALIK, ASRAR B. · 2017 to 2019
$2.7M
Mechanisms of Repair of the Alveolar Epithelium after Lung InjuryR01HL131608 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEMANS, RACHEL LYNNE · 2016 to 2020
$1.9M
Role of TGFβ/BMP Antagonism in Regeneration of the Alveolar Epithelium After Lung InjuryR01HL147920 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZEMANS, RACHEL LYNNE · 2020 to 2021
$992k
Profiling the Lung Transcriptome for Precision Diagnosis of Respiratory Infections using Host/Pathogen Metagenomic SequencingK23HL138461 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2018 to 2021
$718k
HLS13-13 Albumin nanoparticle based technology to treat ARDSR41HL126456 · NHLBI · CELL BIOLOGICS, INC. · PI BACHMAIER, KURT · 2015 to 2016
$688k
CIHR Banting Post-doctoral fellowshipMedical Research Council MR/N021185/1NHLBI NIH HHS K23 HL138461NHLBI NIH HHS R01 HL131608NHLBI NIH HHS R01 HL134828NHLBI NIH HHS R37 HL051856NHLBI NIH HHS R41 HL126456NHLBI NIH HHS R42 HL126456NIDDK NIH HHS T32 DK007573NIH HHS HL126456NIH HHS HL134828NIH HHS R01 HL131608NIH HHS R37 HL51856NIH HHS T32DK007573-23
6 · The paper itself

Abstract

Few patients with bacteremia from a nonpulmonary source develop acute respiratory distress syndrome (ARDS). However, the mechanisms that protect the lung from injury in bacteremia have not been identified. We simulated bacteremia by adding

Indexed as

Acute Lung InjuryAdultBacteremiaEpitheliumFemaleHumansLungMacrophagesMaleMiddle AgedNeutrophilsPermeabilityPneumococcal InfectionsPulmonary AlveoliRespiratory Distress SyndromeRespiratory Mucosaacute lung injuryARDSepithelial injurysepsisshock

Identifiers

PMID32519893
PMCPMC7473934
OpenAlexW3033969504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.