SynthesisPediatric pulmonology2020
What we know so far about Coronavirus Disease 2019 in children: A meta-analysis of 551 laboratory-confirmed cases.
Synthesis in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review.BMC medicine · 2024Pooled it
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Setting-specific Transmission Rates: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- COVID-19 under 19: A meta-analysis.Pediatric pulmonology · 2021Pooled it
- What we know so far about Coronavirus Disease 2019 in children: A meta-analysis of 551 laboratory-confirmed cases.Pediatric pulmonology · 2020Pooled it
- Mortality and risk factors for COVID-19 in hemodialysis patients: A systematic review and meta-analysis.Science progressPooled it
- Gastrointestinal and hepatic manifestations among hospitalized COVID-19 children.BMC pediatrics · 2025Article
- COVID-19 Infection in Pediatric Patients Presenting to a Tertiary Center in Jordan: Clinical Characteristics and Age-Related Patterns.Journal of clinical medicine · 2025Article
- Clinical presentation and management of multisystem inflammatory syndrome in children associated with covid-19: a retrospective observational descriptive study in a pediatric hospital in Syria.BMC infectious diseases · 2024Observational
- Clinical Manifestations Laboratory Tests Abdominal Ultrasonic Findings and In-hospital Prognosis of COVID-19 in 185 Pediatric Cases in a Tertiary Center.Archives of Iranian medicine · 2023Article
- Clinical Hematochemical Parameters in Differential Diagnosis between Pediatric SARS-CoV-2 and Influenza Virus Infection: An Automated Machine Learning Approach.Children (Basel, Switzerland) · 2023Article
- Hemogram-based decision tree models for discriminating COVID-19 from RSV in infants.Journal of clinical laboratory analysis · 2023Article
- Clinical and Epidemiological Presentation of COVID-19 among Children in Conflict Setting.Children (Basel, Switzerland) · 2022Article
- Symptom clusters helping the assessment of SARS-COV-2-infected children: Amiens cohort versus European data.Medicine · 2022Review
- Gastrointestinal and Liver Manifestations in Children with COVID-19 and Their Relationship to Clinical Course.Turkish archives of pediatrics · 2022Article
- Renal manifestations of COVID 19 in children.Journal of family medicine and primary care · 2022Review
- Incidental occurrence of neutropenia in children hospitalised for COVID-19.Italian journal of pediatrics · 2022Article
- Secondary household transmission of SARS-CoV-2 among children and adolescents: Clinical and epidemiological aspects.Pediatric pulmonology · 2022Article
- SARS-CoV-2 Spike Glycoprotein S1 Induces Neuroinflammation in BV-2 Microglia.Molecular neurobiology · 2022Article
- Epidemiology of SARS-CoV-2 infection and SARS-CoV-2 positive hospital admissions among children in South Africa.Influenza and other respiratory viruses · 2022Article
- Deaths in Children and Adolescents Associated With COVID-19 and MIS-C in the United States.Pediatrics · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo summarize what we know so far about coronavirus disease (COVID-19) in children.
methodWe searched PubMed, Scientific Electronic Library Online, and Latin American and Caribbean Center on Health Sciences Information from 1 January 2020 to 4 May 2020. We selected randomized trials, observational studies, case series or case reports, and research letters of children ages birth to 18 years with laboratory-confirmed COVID-19. We conducted random-effects meta-analyses to calculate the weighted mean prevalence and 95% confidence interval (CI) or the weighted average means and 95% CI.
resultForty-six articles reporting 551 cases of COVID-19 in children (aged 1 day-17.5 years) were included. Eighty-seven percent (95% CI: 77%-95%) of patients had household exposure to COVID-19. The most common symptoms and signs were fever (53%, 95% CI: 45%-61%), cough (39%, 95% CI: 30%-47%), and sore throat/pharyngeal erythema (14%, 95% CI: 4%-28%); however, 18% (95% CI: 11%-27%) of cases were asymptomatic. The most common radiographic and computed tomography (CT) findings were patchy consolidations (33%, 95% CI: 23%-43%) and ground glass opacities (28%, 95% CI: 18%-39%), but 36% (95% CI: 28%-45%) of patients had normal CT images. Antiviral agents were given to 74% of patients (95% CI: 52%-92%). Six patients, all with major underlying medical conditions, needed invasive mechanical ventilation, and one of them died.
conclusionPreviously healthy children with COVID-19 have mild symptoms. The diagnosis is generally suspected from history of household exposure to COVID-19 case. Children with COVID-19 and major underlying condition are more likely to have severe/critical disease and poor prognosis, even death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.