Evidence map›Paper›PMID 32519783›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

TOK channels use the two gates in classical K

Anthony Lewis, Zoe A McCrossan, Rían W Manville, M Oana Popa, Luis G Cuello, Steve A N Goldstein

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 2 countries.

Anthony LewisSchool of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
Zoe A McCrossanNIHR Evaluation, Trials and Studies Coordinating Centre (NETSCC), University of Southampton, Southampton, UK.
Rían W ManvilleSchool of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.
M Oana PopaSussex Drug Discovery Centre, School of Life Sciences, University of Sussex, Brighton, UK.
Luis G CuelloDepartment of Cell Physiology and Molecular Biophysics, Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX, 79430, USA.
Steve A N GoldsteinDepartments of Physiology & Biophysics and Pediatrics, School of Medicine, Samueli College of Health Sciences, University of California, Irvine, Irvine, CA, USA.
NIHR Evaluation Trials and Studies Coordinating Centre · GBTexas Tech University Health Sciences Center · USUniversity of Brighton · GBUniversity of California, Irvine · USUniversity of Portsmouth · GBUniversity of Sussex · GB

Funding

OAT--A NOVEL CARDIAC POTASSIUM CHANNEL WITH 2 P DOMAINSR01HL061657 · NHLBI · YALE UNIVERSITY · PI GOLDSTEIN, STEVE A N · 1999 to 2008
$3.6M
High-resolution crystallographic and functional studies of K+ channel gatingR01GM097159 · NIGMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI CUELLO, LUIS GONZALO · 2012 to 2021
$2.7M
STRUCTURE AND FUNCTION OF THE TOK1 POTASSIUM CHANNELR01GM054237 · NIGMS · YALE UNIVERSITY · PI GOLDSTEIN, STEVE A N · 1996 to 2004
$2.3M
A New Family of Voltage-gated Potassium Channel Regulaory SubunitsR01NS058505 · NINDS · UNIVERSITY OF CHICAGO · PI GOLDSTEIN, STEVE A N · 2007 to 2011
$2.3M
De novo protein neurotoxins for ion channelsR01GM111716 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GOLDSTEIN, STEVE A N · 2015 to 2018
$1.2M
Biotechnology and Biological Sciences Research Council BB/J006114/1NHLBI NIH HHS R01 HL061657NIGMS NIH HHS R01 GM054237NIGMS NIH HHS R01 GM097159NIGMS NIH HHS R01 GM111716NINDS NIH HHS R01 NS058505
6 · The paper itself

Abstract

TOKs are outwardly rectifying K

Indexed as

Electric ConductivityAmino Acid SequenceAnimalsCandida albicansCloning, MolecularComputational BiologyCryptococcus neoformansIon Channel GatingMembrane PotentialsOocytesPotassiumPotassium ChannelsSaccharomyces cerevisiaeSequence HomologyXenopus laevisPotassiumPotassium ChannelsAspergillusCandidaCryptococcusgatingpotassiumselectivity

Identifiers

PMID32519783
PMCPMC7501187
OpenAlexW3027999390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.