ArticleJournal of biomedical optics2020
Intraoperative fluorescence perfusion assessment should be corrected by a measured subject-specific arterial input function.
Article in Journal of biomedical optics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Implementation of a Prospective, Multi-Center Clinical Study of Dynamic Contrast Fluorescence Imaging to Diagnose Necrotizing Soft-Tissue Infection - Challenges and Lessons Learned.Proceedings of SPIE--the International Society for Optical Engineering · 2026Article
- Quantitative intra-arterial fluorescence angiography for direct monitoring of peripheral revascularization effects.Journal of vascular surgery cases and innovative techniques · 2025Article
- Dual-channel pulse-dye densitometry can enable correction of fluorescent targeted and control agent plasma input function differences for quantitative paired-agent molecular imaging: a simulation study.Journal of biomedical optics · 2025Article
- Establishing reference curves for vital tissue perfusion using quantitative near-infrared fluorescence imaging with indocyanine green.Langenbeck's archives of surgery · 2025Article
- Patient-specific arterial input function for accurate perfusion assessment in intraoperative fluorescence imaging.Journal of biomedical optics · 2024Article
- Perfusion assessment by fluorescence time curves in esophagectomy with gastric conduit reconstruction: a prospective clinical study.Surgical endoscopy · 2023Article
- Understanding fluorescence time curves during ileal pouch-anal anastomosis with or without vascular ligation.Surgical endoscopy · 2023Article
- High-energy open-fracture model with initial experience of fluorescence-guided bone perfusion assessment.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Current and Future Applications of Fluorescence Guidance in Orthopaedic Surgery.Molecular imaging and biology · 2023Review
- Intraoperative assessment of bone viability through improved analysis and visualization of dynamic contrast-enhanced fluorescence imaging: technique report.OTA international : the open access journal of orthopaedic trauma · 2022Article
- Spatial and temporal patterns in dynamic-contrast enhanced intraoperative fluorescence imaging enable classification of bone perfusion in patients undergoing leg amputation.Biomedical optics express · 2022Article
- Quantitative dynamic near-infrared fluorescence imaging using indocyanine green for analysis of bowel perfusion after mesenteric resection.Journal of biomedical optics · 2021Article
- ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study.Proceedings of SPIE--the International Society for Optical Engineering · 2021Article
- Evaluation of bone perfusion during open orthopedic surgery using quantitative dynamic contrast-enhanced fluorescence imaging.Biomedical optics express · 2020Article
- Perspective on optical imaging for functional assessment in musculoskeletal extremity trauma surgery.Journal of biomedical optics · 2020Article
- Early identification of life-threatening soft-tissue infection using dynamic fluorescence imaging: first-in-kind clinical study of first-pass kinetics.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Fluorescence-guided and molecularly-guided debridement: identifying devitalized and infected tissue in orthopaedic trauma.Proceedings of SPIE--the International Society for Optical EngineeringArticle
- Dynamic contrast-enhanced fluorescence imaging compared with MR imaging in evaluating bone perfusion during open orthopedic surgery.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
significanceThe effects of varying the indocyanine green injection dose, injection rate, physiologic dispersion of dye, and intravenous tubing volume propagate into the shape and magnitude of the arterial input function (AIF) during intraoperative fluorescence perfusion assessment, thereby altering the observed kinetics of the fluorescence images in vivo.
aimNumerical simulations are used to demonstrate the effect of AIF on metrics derived from tissue concentration curves such as peak fluorescence, time-to-peak (TTP), and egress slope. APPROACH: Forward models of tissue concentration were produced by convolving simulated AIFs with the adiabatic approximation to the tissue homogeneity model using input parameters representing six different tissue examples (normal brain, glioma, normal skin, ischemic skin, normal bone, and osteonecrosis).
resultsThe results show that AIF perturbations result in variations in estimates of total intensity of up to 80% and TTP error of up to 200%, with the errors more dominant in brain, less in skin, and less in bone. Interestingly, error in ingress slope was as high as 60% across all tissue types. These are key observable parameters used in fluorescence imaging either implicitly by viewing the image or explicitly through intensity fitting algorithms. Correcting by deconvolving the image with a measured subject-specific AIF provides an intuitive means of visualizing the data while also removing the source of variance and allowing intra- and intersubject comparisons.
conclusionsThese results suggest that intraoperative fluorescence perfusion assessment should be corrected by patient-specific AIFs measured by pulse dye densitometry.
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