ArticlePhysiological reports2020
Fasting blood triglycerides vary with circadian phase in both young and older people.
Article in Physiological reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Modulation of the Serum Metabolome by the Short-Chain Fatty Acid Propionate: Potential Implications for Its Cholesterol-Lowering Effect.Nutrients · 2024Trial
- Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance.Sleep · 2022Trial
- Association between time-of-day plasma lipid measurements and acute kidney injury in critically ill patients: A retrospective cohort study.SAGE open medicine · 2026Article
- Sleep and circadian effects on the incretin system.Current sleep medicine reports · 2025Article
- Circadian Rhythms in Aging and Age-Related Neurogenerative Disease.Current sleep medicine reports · 2025Article
- Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches.Cells · 2025Review
- Bright night sleeping environment induces diabetes and impaired glucose tolerance in non-human primates.Frontiers in endocrinology · 2025Article
- Relationship of cardiometabolic disease risk factors with age and spinal cord injury duration.The journal of spinal cord medicine · 2024Article
- Research progress of circadian rhythm in cardiovascular disease: A bibliometric study from 2002 to 2022.Heliyon · 2024Review
- Eating during the biological night is associated with nausea.Sleep health · 2024Article
- Brain Dopamine-Clock Interactions Regulate Cardiometabolic Physiology: Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed Bromocriptine-QR Therapy in Type 2 Diabetes Subjects.International journal of molecular sciences · 2023Review
- Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period.Nature protocols · 2023Review
- Article
- Harm of circadian misalignment to the hearts of the adolescent wistar rats.Journal of translational medicine · 2022Article
- Chronic circadian disruption on a high-fat diet impairs glucose tolerance.Metabolism: clinical and experimental · 2022Article
- The Association of Dietary Vitamin Intake Time Across a Day With Cardiovascular Disease and All-Cause Mortality.Frontiers in cardiovascular medicine · 2022Article
- Fasting blood triglycerides vary with circadian phase in both young and older people.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Daily rhythms in several physiological processes are important for cardiometabolic health. The lipid panel is used clinically to assess cardiovascular disease risk, but previous attempts to demonstrate circadian variation in lipids have failed to uncouple the endogenous circadian rhythm from the effects of meals and wake duration. Changes in basal lipid levels and dampening of circadian rhythms have been reported with aging, but it is unknown whether aging is also associated with changes in the rhythmic variation of lipids. We measured fasting lipid panels (triglycerides, total cholesterol, high-density lipoprotein, and low-density lipoprotein) in blood at wake time in 21 healthy adults using a specialized laboratory protocol that uncouples sleep-wake and activity-related effects from the endogenous circadian rhythm. Young and older adults exhibited endogenous circadian variations in fasting triglycerides, with both groups peaking in the early biological morning. Young adults also exhibited significant circadian rhythmicity in total cholesterol and low-density lipoprotein, while older adults did not exhibit circadian rhythmicity in any other lipids. These results reveal that triglyceride metabolism may be regulated by the central circadian pacemaker. Moreover, our findings may have clinical implications in assessing cardiovascular risk in shift workers and younger adults, since routine measurement of morning/fasting lipids may not fully and reliably assess triglyceride- and other lipid-related biomarkers of cardiovascular disease risk in these groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.