ArticleChemphyschem : a European journal of chemical physics and physical chemistry2020
Speeding up Viedma Deracemization through Water-catalyzed and Reactant Self-catalyzed Racemization.
Article in Chemphyschem : a European journal of chemical physics and physical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 9 citations in OpenAlex.
- Autocatalytic photoredox Chan-Lam coupling of free diaryl sulfoximines with arylboronic acids.Nature communications · 2021Article
- Speeding up Viedma Deracemization through Water-catalyzed and Reactant Self-catalyzed Racemization.Chemphyschem : a European journal of chemical physics and physical chemistry · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Viedma deracemization is based on solution phase racemization, dissolution of racemic or scalemic conglomerates and crystal growth through autocatalytic cluster formation. With rate limiting racemization, its acceleration by appropriate catalysts may result in speeding up deracemization. A conglomerate-forming chiral compound may principally racemize directly, or via reverse of its formation reaction. For a hydrazine derivative, we investigated available racemization pathways in presence of pyrrolidine or thiourea amine as base catalysts: via Mannich or aza-Michael reaction steps and their reverse, or by enolization. Racemization by enolization was computationally found to dominate, both under water-free conditions and in presence of water, involving a multitude of different pathways. Faster racemization in presence of water resulted indeed in more rapid deracemization, when the base was pyrrolidine. Under water-free conditions, the role of water as enolization catalyst is assumed by chiral hydrazine itself - in autocatalytic racemization and in which both reactant and product are catalysts.
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Registered trials
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