Evidence map›Paper›PMID 32519319›Full record

ArticleActa neurologica Belgica2021

Cerebrospinal fluid findings in patients with hematologic neoplasms and meningeal infiltration.

Renan Barros Domingues, Fernando Brunale Vilela de Moura Leite, Carlos Senne

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In one paragraph

Article in Acta neurologica Belgica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Renan Barros DominguesSenne Liquor Diagnóstico, São Paulo, SP, Brazil. renan.domingues@senneliquor.com.br.ORCID http://orcid.org/0000-0002-6058-7937
Fernando Brunale Vilela de Moura LeiteSenne Liquor Diagnóstico, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0003-2661-1523
Carlos SenneSenne Liquor Diagnóstico, São Paulo, SP, Brazil.
Serviço Nacional de Aprendizagem Comercial · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neoplastic cell infiltration into the central nervous system (CNS) is a serious complication of hematological neoplasms. Cytomorphology (CM) and flow cytometry (FC) have been used to detect meningeal infiltration. The association between CSF findings with the results of CM and FC is still poorly understood. We retrospectively evaluated CSF findings in 72 patients with hematological neoplasm and meningeal infiltration detected either by CM or FC. We compared CSF cell count, total protein concentration, and lactate concentration according to the type of hematological neoplasm. We also compared these CSF findings according to the FC and CM results (FC + CM + , FC + CM-, and FC-CM +). The proportion of patients with positive FC was higher than with CM (FC - 91.7%; CM - 63.9%). Thirty-five (48.6%) patients with meningeal infiltration had normal CSF cell count, normal total protein concentration, and normal lactate concentration. The proportion of cases in which these CSF parameters were normal did not differ according to the type of hematological neoplasm. The positivity of CM was significantly higher in patients with > 3 cell/mm

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersChildChild, PreschoolFemaleFlow CytometryHematologic NeoplasmsHumansInfantLactic AcidMaleMeningeal NeoplasmsMiddle AgedBiomarkersLactic AcidCerebrospinal fluidCytomorphologyFlow cytometryHematological neoplasmMeningeal infiltration

Identifiers

PMID32519319
OpenAlexW3033386954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.