Evidence map›Paper›PMID 32519314›Full record

ArticleClinical journal of gastroenterology2020

Double small bowel cancers leading to the diagnosis of Lynch syndrome with germline MSH6 mutation in an elderly patient.

Sae Ohwada, Kentaro Yamashita, Tomoe Kazama, Kei Mitsuhashi, Akiko Ichiyanagi, Kohei Nakachi, Hiro-O Yamano, Takayuki Nobuoka, Tatsuya Ito, Wataru Sasao and 1 more

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Sae OhwadaDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Kentaro YamashitaDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan. ykentaro313@gmail.com.ORCID http://orcid.org/0000-0001-9003-9846
Tomoe KazamaDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Kei MitsuhashiDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Akiko IchiyanagiDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Kohei NakachiDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Hiro-O YamanoDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Takayuki NobuokaDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Tatsuya ItoDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Wataru SasaoDepartment of Internal Medicine, Hokkaido Haboro Hospital, Haboro, Japan.
Hiroshi NakaseDepartment of Gastroenterology and Hepatology, Sapporo Medical University, S1W16, Chuo-ku, Sapporo, 060-8543, Japan.
Sapporo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A female patient in her 80s was referred to our hospital because of an ileal tumor identified by capsule endoscopy. FDG-PET suggested double intestinal tumors not only in the ileum but also in the jejunum. The patient has cancer past history including sigmoid colon, rectum, and endometrium, and also had cancer family history fulfilling the revised Amsterdam criteria. Double balloon enteroscopy disclosed two ulcerated tumors in the jejunum and the ileum. Biopsy was diagnosed as adenocarcinoma pathologically, and microsatellite instability-high (MSI-H) genetically. Surgical resection was performed, and the jejunal and the ileal tumors were tubular (T2N0M0) and mucinous adenocarcinoma (T4N0M0), respectively. Germline mutation analysis revealed a pathogenic splice-site mutation in MSH6.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisIleal NeoplasmsAgedDNA-Binding ProteinsFemaleGerm CellsGerm-Line MutationHumansMutationDNA-Binding ProteinsG-T mismatch-binding proteinCapsule endoscopyLynch syndromeSmall bowel cancer

Identifiers

PMID32519314
OpenAlexW3033130501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.